Tardive Dyskinesia: Treatment Update

AbstractPurpose of ReviewTardive dyskinesia (TD) is caused by exposure to medications with dopamine antagonism, mainly antipsychotics. It often distresses individuals, physically and emotionally and affects their quality of life. We evaluated peer-reviewed recently published articles with a goal of providing a critically appraised update on the latest advancements in this field.Recent FindingsIn 2017, FDA approved VMAT2 inhibitors, deutetrabenazine and valbenazine. They have demonstrated efficacy in several class 1 studies. Also there have been update in the evidence-based guidelines for treatment for tardive dyskinesia.SummaryVarious medication classes are being used for treatment of TD with VMAT2 inhibitors to be first FDA-approved medications. Their use should be tailored to the individual patient. Long-term studies will further guide us in how to optimize treatment, especially in the real-world setting. As clinicians, we need to take into consideration all aspects of symptomatology, etiology, potential side effects of the medications, to find the best possible “match” for our patients.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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Authors: Artukoglu BB, Li F, Szejko N, Bloch MH Abstract OBJECTIVE: To examine the efficacy of pharmacologic treatments for tardive dyskinesia (TD). DATA SOURCES: PubMed was searched on December 12, 2017, for randomized, placebo-controlled trials examining the treatment of TD using the search terms (drug-induced dyskinesia OR tardive dyskinesia) AND (psychotic disorders OR schizophrenia). STUDY SELECTION: Studies were included if they examined tardive dyskinesia treatment as the primary outcome and were randomized and placebo-controlled trials. DATA EXTRACTION: The effect size (standard mean difference)...
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