Retrospective follow-up analysis of the transcriptomic patterns of cytokines, cytokine receptors and chemokines at preconception and during pregnancy, in women with post-partum depression.

Retrospective follow-up analysis of the transcriptomic patterns of cytokines, cytokine receptors and chemokines at preconception and during pregnancy, in women with post-partum depression. Exp Ther Med. 2019 Sep;18(3):2055-2062 Authors: Petralia MC, Mazzon E, Fagone P, Falzone L, Bramanti P, Nicoletti F, Basile MS Abstract Post-partum depression (PPD) occurs in approximately 20% of women usually early following child delivery. PPD represents an important unmet medical need as it is frequently underdiagnosed and, as the neurobiology of the disease is limitedly known, no pathogenic-tailored approach is available and only symptomatic medications are used. In the present study, we carried out a DNA microarray analysis to evaluate the fluctuation of cytokines, cytokine receptors and chemokines during the preconception period, the 1st and 3th trimester of pregnancy and the early post-partum period. The data demonstrated that, as compared to always-depressed patients and euthymic controls, women who developed PPD exhibited significant fluctuations in the levels of different cytokines and cytokine receptors, primarily related to tumor necrosis factor (TNF) and interleukin (IL)18. These data emphasize the role of the immune system in PPD. However, additional studies aimed at evaluating if and how these functional modifications of the immune system during pregnancy are related to the development of PPD warranted to confirm our findings. PMID: 31410161 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research

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Conclusions: As a comprehensive scale, PPNMSS is efficient to measure PNMS, which facilitates an early detection of stress and depression among pregnant women and timely intervention by health care professionals.
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
CONCLUSIONS: Women with higher fish and/or n-3 PUFA intake showed reduced risk of postpartum depression at 6 months after delivery and of serious mental illness at 1 year after delivery. PMID: 31535610 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
In this study we examined the extent to which postnatal bonding, maternal mental health, and substance use at 8-weeks postpartum predicted mother –infant bonding (self-report) and mother emotional availability (observational) at 12-months of age.MethodsData were obtained from an Australian longitudinal cohort study of pregnancy (n  = 308). Data were collected during pregnancy, at birth, and postnatally at 8-weeks and 12-months.ResultsThe results show strong continuity between postnatal bonding at 8-weeks and 12-months. Early postpartum stress and depression were associated with bonding at 12-months; how...
Source: Maternal and Child Health Journal - Category: Health Management Source Type: research
Authors: Gordon H, Nath S, Trevillion K, Moran P, Pawlby S, Newman L, Howard LM, Molyneaux E Abstract OBJECTIVE: To investigate the association between maternal self-harm (lifetime history of self-harm and self-harm ideation during pregnancy) and mother-infant interactions in a representative cohort from southeast London. METHODS: Data were drawn from a prospective cohort of 545 women attending antenatal appointments between 2014 and 2016. Women were asked about history of self-harm and current self-harm ideation during a research interview following first antenatal visit. Follow-up data on depressive symptoms ...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Astudy inAJP in Advance provides further evidence that the detrimental effects of adverse life experiences can carry across generations. Researchers found that children of mothers who experienced stressful events during childhood had greater biological signs of stress and were more likely to have behavioral problems at 18 months.“[O]ur data, when combined with findings from other studies, confirm maternal life-course experiences as a potent predictor of offspring mental and physical well-being,” wrote Kyle Esteves, M.P.H., of Tulane University School of Medicine and colleagues. “Our results suggest that s...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance anxiety depression early life adversity externalizing problems generational effects internalizing problems Kyle Esteves mental health pregnant women telomeres Source Type: research
Publication date: Available online 11 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jingwen Lang, Bingqian Zhang, Yueru Meng, Yanzhi Du, Linlin Cui, Weiping LiABSTRACTResearch QuestionAre maternal depression and anxiety disorders (MDAD) before and during pregnancy associated with in vitro fertilization (IVF) outcomes?DesignA total of 5556 women with their first IVF cycle started between August 15th, 2014, and December 31st, 2015 were pooled from a prospective cohort of assisted reproductive technology (ART) children. The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to d...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
[Nigeria Health Watch] "I felt thoroughly inadequate. I didn't feel like I was attractive enough. I didn't feel like I was doing enough. Nobody told me I could feel that way"  -- Patience, Post Partum Depression Survivor
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
Publication date: Available online 8 September 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Andrée-Anne Hudon Thibeault, Yossef López de Los Santos, Nicolas Doucet, J. Thomas Sanderson, Cathy VaillancourtAbstractSerotonin reuptake inhibitors (SRIs) are currently the main molecules prescribed to pregnant women that suffer from depression. Placental cells are exposed to SRIs via maternal blood, and we have previously shown that SRIs alter feto-placental steroidogenesis in an in vitro co-culture model. More specifically, serotonin (5-HT) regulates the estrogen biosynthetic enzy...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
CONCLUSION: Though absolute numbers were modest, severe maternal morbidity was associated with increased risk of severe postpartum psychiatric morbidity and substance use disorder. The highest period of risk extended to 4 months after hospital discharge. PMID: 31503165 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
CONCLUSION: Pregnancy offered a pivotal opportunity for homeless women to engage with care for their complex needs and improve self-care, despite mistrust of practitioners. Poor postnatal support and the distress of CLSS reinforced an ongoing cycle of grief, mental health crises, substance use relapse, and homelessness. PMID: 31501164 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - Category: Primary Care Authors: Tags: Br J Gen Pract Source Type: research
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