Diagnosis and epidemiology of Leishmania infantum in domestic cats in an endemic area of the Amazon region, Brazil

Publication date: Available online 15 August 2019Source: Veterinary ParasitologyAuthor(s): Ana Vitória Verde Oliveira Rocha, Brenda Fernanda Sodré Moreno, Aline Diniz Cabral, Nayara Mendes Louzeiro, Leandro Macedo Miranda, Vivian Magalhães Brandão dos Santos, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Arlei Marcili, Márcia Aparecida Sperança, Andréa Pereira da CostaAbstractVisceral leishmaniasis is a zoonotic disease caused by Leishmania infantum for which dogs are the main reservoir. In South America, presence of this disease is expanding along with increasing dispersion of its principal vector, the sand-fly Lutzomyia longipalpis. Feline leishmaniasis is an emerging disease in domestic cats, but epidemiological studies in endemic areas of the Amazon region of Brazil are scarce and the role of cats as reservoirs of L. infantum has been debated. The aim of this study was to investigate L. infantum infection in cats living in the Amazon biome region, using serological and molecular methods. A total of 105 cats were subjected to clinical examination and blood samples were taken for immunofluorescent-antibody (IFAT) serological evaluation, to determine anti-Leishmania antibody titers. Conventional PCR and Sanger’s sequencing targeting L. infantum chitinase and Leishmania species ribosomal internal transcribed spacer (ITS-1) encoding genes were performed on conjunctival swabs from these cats. Seropositivity was det...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research

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This study was designed to evaluate the clinical efficacy, recurrence rate, and safety of the new therapy with oral glycyrrhizin in adult patients with mild to moderate active AA.MethodsIt was a randomized controlled trial using two oral tablets of 25 mg glycyrrhizin three times per day (tid) for test group (65 patients), or two oral tablets of 25 mg cystine tid for the control (56 cases). Patients in both groups were also treated with topical 0.05% halometasone cream twice daily (bid). The treatment period was 24 weeks, including 12 weeks of active therapy, followed by another 12 weeks of observation.Results...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionsPRDR radiation therapy with capecitabine were well tolerated and effective method for treating patients with recurrent breast cancer. Prospective studies are necessary to compare side effects and efficacy with conventional dose rate re-irradiation, as well as, to evaluate the potential role for capecitabine in the recurrent setting.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionStrict monitoring and control of hemodynamic parameters as well as meticulous fluid therapy is the cornerstone in improving outcome in patients with dilated cardiomyopathy undergoing renal transplant surgery.ResumoJustificativa e objetivosA cardiomiopatia dilatada é um estado de aumento progressivo das câmaras cardíacas, principalmente do ventrículo esquerdo, que leva à diminuição do débito cardíaco e, por fim, à insuficiência cardíaca. Embora tenha etiologia multifatorial, é bastante comum em pacientes com doença rena...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Abstract A new method to determine the total titratable acidity of orange, lemon and passion fruit, based on a spot test obtained from digital images and using anthocyanins as the biodegradable indicator, is presented for the first time. The colorimetric reactions were carried out by acid-base titration on a microscale, employing anthocyanin with a microplate for spot test purposes, with detection by digital imaging. To obtain highly precise data, a chamber based on a diffuser was developed to control the illumination supplied by the light emitting diodes, and coupled to a smartphone to acquire adequate digital im...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Publication date: Available online 14 September 2019Source: Food Research InternationalAuthor(s): Bruno Luís Ferreira, Luciano Valdemiro Gonzaga, Luciano Vitali, Gustavo Amadeu Micke, Heloisa França Maltez, Carolina Ressureição, Ana Carolina Oliveira Costa, Roseane FettAbstractGeopropolis is a stingless bee product compose mainly by soil, presenting complex composition geopropolis has bioactive compounds that will depend on geographical characteristics as well bee species, changing their chemical and biological properties. Thus the study aims to evaluate the solubility and chemical stability of ...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 14 September 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Paul McCusker, John D. ChanAbstractSubversion of parasite neuromuscular function is a key strategy for anthelmintic drug development. Schistosome Ca2+ signaling has been an area of particular interest for decades, with a specific focus on L-type voltage-gated Ca2+ channels (Cavs). However, the study of these channels has been technically challenging. One barrier is the lack of pharmacological probes that are active on flatworms, since the dihydropyridine (DHP) based ligands typically used ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
Publication date: Available online 14 September 2019Source: Plant ScienceAuthor(s): Yanfeng Hu, Jia You, Chunjie Li, Fengjuan Pan, Congli WangAbstractSoybean cyst nematode (Heterodera glycines Ichinohe) is a sedentary root endoparasite that causes serious yield losses on soybean (Glycine max) worldwide. H. glycines secrets effector proteins into host cells to facilitate the success of parasitism. Nowadays, a large number of candidate effectors were identified from the genome sequence of H. glycines. However, the precise functions of these effectors in the nematode-host plant interaction are unknown. Here, an effector gene ...
Source: Plant Science - Category: Biology Source Type: research
CONCLUSIONS: To the best of our knowledge, this is the first report of spontaneous bleeding probably caused by Exenatide. The exact pathophysiology, by which the drug can cause spontaneous bleeding, is still not clear and has to be revealed. PMID: 31517602 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
CONCLUSIONS: Our results indicate that the TCF7L2 rs12255372 and rs7903146 polymorphisms do not influence T2DM in Brazilian patients with the high risk for CAD. Therefore, we assume that these variants may only be relevant for a specific subgroup of T2DM patients or some particular human population. PMID: 31517619 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
Publication date: Available online 14 September 2019Source: Comparative Biochemistry and Physiology Part A: Molecular &Integrative PhysiologyAuthor(s): Monica Vanessa Garduño Paz, José Fernando Méndez Sánchez, Warren Burggren, José Luis Antonio García MartínezAbstractThe darkedged splitfin (Amarillo fish), Girardinichthys multiradiatus is a vulnerable endemic fish species inhabiting central Mexico's high altitude Upper Lerma Basin, where aquatic hypoxia is exacerbated by low barometric pressures (lower PO2s), large aquatic oxygen changes, poor aquatic systems management ...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
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