Heterogeneity of Highly Susceptible Yersinia enterocolitica Isolates of Clinical and Environmental Origin: A 5-Year Survey from Iran (2011 –2016)

Microbial Drug Resistance, Ahead of Print.
Source: Microbial Drug Resistance - Category: Microbiology Authors: Source Type: research

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Abstract BACKGROUND: Whole blood (WB) is held at room temperature for not more than 24 hours before blood component manufacturing. The ability of several culture collection, skin-derived, and transfusion-related bacteria to survive in WB stored at 22 ± 2°C for 24 hours was investigated in this study. STUDY DESIGN AND METHODS: Twenty-one bacteria of the species Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus capitis, Streptococcus agalactiae, Serratia liquefaciens, Serratia marcescens, Klebsiella pneumoniae, Escherichia coli, and Yersinia enterocolitica ...
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
NIH Director ’ s Wednesday Afternoon Lecture Series Ralph Isberg has been a Professor of Molecular Biology and Microbiology at Tufts University School of Medicine for 32 years. After receiving an undergraduate degree at Oberlin College, he obtained his PhD at Harvard working on transposable genetic elements in bacteria. Throughout his career at Tufts he has primarily focused on the pathogenesis of Legionella pneumophila and enteropathogenic Yersinia, and has recently initiated projects on tackling drug resistance in nosocomial organisms. His research highlights include the identification of proteins involved in uptak...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Conclusion: Due to the high number of the population involved in raising small ruminants the risk to veterinary and public health must be rapidly determined.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
Abstract Burkholderia pseudomallei (B. pseudomallei), the etiological agent of melioidosis, is a Gram-negative bacterium with additional concern as a biothreat pathogen. The mortality rate from B. pseudomallei varies depending on the type of infection and extent of available health care, but in the case of septicemia left untreated it can range from 50 - 90%. Current therapy for melioidosis is biphasic, consisting of parenteral acute-phase treatment for two weeks or longer, followed by oral eradication-phase treatment lasting several months. An effective oral therapeutic for outpatient treatment of acute-phase mel...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (10069) engineered with yopK yopJ asd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopENt138-LcrV), to Swiss Webster mice as a protective antigen against infections by yersiniae. 10069 bacteria harboring the pYA5199 plasmid constitutively synthesized the YopENt138-LcrV fusion protein and secreted it via the type 3 secretion system (T3SS) at 37°C under calcium-deprived conditions. The attenuated strain 10069(pYA5199) was manifested by the establishment of controlled infection in differ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Microbial Immunity and Vaccines Source Type: research
To successfully colonize host tissues, bacteria must respond to and detoxify many different host-derived antimicrobial compounds, such as nitric oxide (NO). NO has direct antimicrobial activity through attack on iron-sulfur (Fe-S) cluster-containing proteins. NO detoxification plays an important role in promoting bacterial survival, but it remains unclear if repair of Fe-S clusters is also important for bacterial survival within host tissues. Here we show that the Fe-S cluster repair protein YtfE contributes to the survival of Yersinia pseudotuberculosis within the spleen following nitrosative stress. Y. pseudotuberculosis...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1570-zThe receptor FPR1 on human immune cells interacts with Yersinia pestis, mutations in this receptor provide resistance against plague in humans and Fpr1 deficiency enhances survival in mice.
Source: Nature AOP - Category: Research Authors: Source Type: research
Publication date: Available online 14 September 2019Source: Journal of Organometallic ChemistryAuthor(s): Dilek Unluer, Ayse Aktas Kamiloglu, Sahin Direkel, Ersan Bektas, Halit Kantekin, Kemal SancakAbstractIn this work, novel metallophthalocyanine compounds (M = Zn, Cu, Co) bearing four 2-methoxy-4-{(Z)-[(4-morpholin-4-ylphenyl)imino]methyl}phenol at the peripheral positions were sythesized starting from the new phthalonitrile derivative (2). These new compounds (2–5) have been characterized by a combination of FT-IR, 1H NMR (for compounds 2 and 3), 13C NMR (for compound 2), UV–Vis (for compounds 3,4 and 5...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
Many pathogenic bacteria use the type III secretion system (T3SS) injectisome to manipulate host cells by injecting virulence-promoting effector proteins into the host cytosol. The T3SS is activated upon host cell contact, and its activation is accompanied by an arrest of cell division; hence, many species maintain a T3SS-inactive sibling population to propagate efficiently within the host. The enteric pathogen Yersinia enterocolitica utilizes the T3SS to prevent phagocytosis and inhibit inflammatory responses. Unlike other species, almost all Y. enterocolitica are T3SS-positive at 37°C, which raises the question, how ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Linke Yersinia ruckeri is the causative agent of enteric redmouth disease, a bacterial infection of marine and freshwater fish. The disease mainly affects salmonids, and outbreaks have significant economic impact on fish farms all over the world. Vaccination routines are in place against the major serotypes of Y. ruckeri but are not effective in all cases. Despite the economic importance of enteric redmouth disease, a detailed molecular understanding of the disease is lacking. A considerable number of mostly omics-based studies have been performed in recent years to identify genes related to Y. ruckeri virulence. This ...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
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