Endothelin type B receptor promotes cofilin rod formation and dendritic loss in neurons by inducing oxidative stress and cofilin activation [Molecular Bases of Disease]

In conclusion, our findings suggest a role for ETB in neurodegeneration by promoting cofilin rod formation and dendritic loss via NOX-driven superoxide formation and cofilin activation.

Source: Journal of Biological Chemistry - August 15, 2019 Category: Chemistry Authors: Sze-Wah Tam, Rui Feng, Way Kwok-Wai Lau, Andrew Chi-Kin Law, Patrick Ka-Kit Yeung, Sookja Kim Chung Tags: Neurobiology Source Type: research