A new small animal model for simulating a two-stage-revision procedure in implant-related methicillin-resistant Staphylococcus aureus bone infection

Orthopedic implant-related infections such as periprosthetic joint infections (PJI) and osteosynthesis related infections are a devastating problem for both patients and surgeons. Besides being potentially life-threatening, implant related infections are a socioeconomic burden due to increasing health-care expenditures, functional impairment and long-lasting disabilities 1. While Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-resistant Staphylococcus aureus (MRSA), coagulase-negative Staphylococcus (CoNS), Streptococcus, and Enterococcus are mainly responsible for PJI, an increase of high-resistance pathogens has occurred within the last years 2.

Source: Injury - August 14, 2019 Category: Orthopaedics Authors: Maximilian Brunotte, Markus Rupp, Sabine St ötzel, Ursula Sommer, Walid Mohammed, Ulrich Thormann, Christian Heiss, Katrin S. Lips, Eugen Domann, Volker Alt Source Type: research