Molecular detection of drug resistant malaria in Southern Thailand

Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia. Plasmodium vivax first-line treatment drug is chloroquine...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research

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Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum parasites and also blocked transmission of sexual stages to the mosquito vector. These compounds were resistant to degradation by serum pantetheinases, showed favorable pharmacokinetic properties, and cleared parasites in a humanized mouse model of P. falciparum infection. Metabolomics revealed that coenzyme A biosynthetic enzymes converted pantothenamides into coenzyme A analog...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Authors: Camarlinghi G, Parisio EM, Nardone M, Mancini F, Ciervo A, Boccolini D, Mattei R Abstract Both malaria and relapsing fever Borrelia are infectious diseases characterized by fever, headache, myalgia, hepatosplenomegaly and tendency to relapse. Exflagellation of microgametocyte in malarial parasites is seen only in the definitive host, i.e., mosquitoes. Here we report an unusual case of a 23-year-old man who presented Plasmodium vivax infection with multiple exflagellated microgametes in the peripheral blood smear. PMID: 31524945 [PubMed - as supplied by publisher]
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Malaria parasites resistant to 2 first-line treatments are spreading rapidly in Southeast Asia, according to a pair of recent studies.
Source: JAMA - Category: General Medicine Source Type: research
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the evolving role of platelets as key sentinel and effector cells in infectious diseases, especially critical in bridging hemostatic, inflammatory, and immune continuums. Upon intravascular pathogen invasion, platelets can directly sense viral, parasitic, and bacterial infections through pattern recognition receptors and integrin receptors or pathogen: immunoglobulin complexes through Fc and complement receptors—although our understanding of these interactions remains incomplete. Constantly scanning for are...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionThe P. berghei ookinete development assay is an excellent high throughput assay for efficiently identifying antimalarial molecules targeting early mosquito stage parasite development. Currently no high throughput transmission-blocking assay is capable of identifying all transmission-blocking molecules.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Primaquine administration results in H2O2 accumulation in bone marrow, where gametocytes and asexual parasites are therefore killed. This finding, by Camarda et al., supports the theory that the nonperipheral blood origin of recurrent Plasmodium vivax malaria is both hypnozoites (relapse source) and merozoites (recrudescence source), not hypnozoites only. PMID: 31522991 [PubMed - as supplied by publisher]
Source: Trends in Parasitology - Category: Parasitology Authors: Tags: Trends Parasitol Source Type: research
The recent resurgence of interest in sterile insect techniques to control vector mosquitoes has renewed interest in novel methods for observing mating behavior. Malarial vectors of the Anopheles gambiae complex a...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Methodology Source Type: research
by David F. Read, Kate Cook, Yang Y. Lu, Karine G. Le Roch, William Stafford Noble Empirical evidence suggests that the malaria parasitePlasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism ’s complex life cycle. To better understand this regulatory machinery, we assembled a rich collection of genomic and epigenomic data sets, including information about transcription factor (TF) binding motifs, patterns of covalent histone modifications, nucleosome occupancy, GC content, and global 3D genome architecture. We used these data to train machine learning models ...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
This study aimed to investigate the effect of MCs activation on malaria disease severity using KunMing mice with Plasmodium berghei ANKA (PbANKA) infection treated with MCs degranulator (compound 48/80, C48/80) or MCs stabilizer (disodium cromoglycate, DSCG). PbANKA infection caused a dramatic increase in MCs density and level of MCs degranulation in cervical lymph node (CLN) and skin. Compared with infected control, C48/80 treatment had shortened survival time, increased parasitemia, exacerbated liver inflammation and CLN hyperplasia, accompanied with increase in vascular leakage and leukocyte number. The infected mice wi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
It may be possible to eradicate malaria—one of history’s deadliest diseases—from the planet by 2050, according to a coalition of 41 leading scientists, economists and health-policy experts writing in the Lancet. “Malaria is one of the oldest and deadliest diseases of humankind,” says Sir Richard Feachem, one of the report’s authors and co-chair of the Lancet commission on malaria eradication. “If we, humankind, were to take on this challenge and eradicate malaria by 2050, it would be an achievement of historic proportions. There would be nothing quite like it.” Malaria, a mos...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease onetime Source Type: news
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