Differential Changes in Functional Connectivity of Striatum-Prefrontal and Striatum-Motor Circuits in Premanifest Huntington's Disease.

CONCLUSIONS: Differential changes in functional connectivity of striatum-prefrontal and striatum-motor circuits can be found in early and premanifest HD. This may imply a compensatory mechanism, where additional cortical regions are recruited to subserve functions that have been impaired due to HD pathology. Our results suggest the potential value of functional connectivity as a marker for future clinical trials in HD.
PMID: 31412344 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - August 13, 2019 Category: Neurology Authors: Kronenbuerger M, Hua J, Bang JYA, Ultz KE, Miao X, Zhang X, Pekar JJ, van Zijl PCM, Duan W, Margolis RL, Ross CA Tags: Neurodegener Dis Source Type: research