Urinary Bladder Weight and Function in a Rat Model of Mild Hyperglycemia and Its Treatment With Dapagliflozin

Hypertrophy and dysfunction of the urinary bladder are consistently observed in animal models of type 1 and less consistently in those of type 2 diabetes. We have tested the effects of mild hyperglycemia (n = 10 per group) in a randomized, blinded study and, in a blinded pilot study, of type 2 diabetes (n = 6 per group) and its treatment with dapagliflozin (1 mg/kg/day) on weight, contraction and relaxation of the rat bladder. Based on a combination of high-fat diet and a low dose of streptozotocin, animals in the main study reached a mean peak blood glucose level of about 300 mg/dl, which declined to 205 mg/dl at study end. This was associated with a small if any increase in bladder weight. In a pooled analysis of all animals of the main and the pilot study, we detected a correlation of moderate strength between blood glucose and bladder weight (r2 = 0.2013; P = 0.0003 for Pearson correlation coefficient). Neither the main nor the pilot study found evidence for an altered contractility (responses to carbachol or KCl) or relaxation (responses to isoprenaline, fenoterol, CL 316,243 or forskolin). Treatment with dapagliflozin in the absence of hyperglycemia increased diuresis in the main study by 43% relative to control and increased bladder weight by 15% in the pooled groups of both studies (post-hoc analysis). We conclude that mild hyperglycemia has no major effects on bladder hypertrophy or function.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Findings based on survey of university - affiliated students, staff with either type 1 or type 2 diabetes
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Endocrinology, Family Medicine, Internal Medicine, Nursing, Pediatrics, Psychiatry, Journal, Source Type: news
Amidst news of several Congressional hearings on the topic earlier in 2019, and continued protests by patient advocates outside of insulin manufacturers'headquarters, as well as persistent patient and caregiver complaints about runaway U.S. insulin prices in the U.S. media, a less-acknowledged change occurred which could impact what many patients with diabetes pay next year for insulin and testing supplies.It's not often that Americans would actually wish to THANK the Treasury Department and the Internal Revenue Service (IRS), but in 2020, perhaps many Americans with diabetes might wish to do that!On July 17, 2019, the IRS...
Source: Scott's Web Log - Category: Endocrinology Tags: 2019 2020 drug prices insulin insulin prices IRS Source Type: blogs
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Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
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Source: Age and Ageing - Category: Geriatrics Source Type: research
Authors: Kutoh E, Hayashi J, Kuto AN Abstract OBJECTIVE: While dulaglutide has been approved inpatients with type 2 diabetes (T2DM) in combination with insulin, it has not been studied in insulin-deficient patients, not whether they have type 1 diabetes (T1DM) or T2DM. The aim of this study is to assess the efficacy and safety of dulaglutide 0.75 mg/once weekly (QW) in patients with absolute insulin deficiency (n=10). SUBJECTS AND RESULTS: Significant reductions of HbA1c (9.30±1.03% to 8.61±1.21%; p
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
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Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
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Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
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Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
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Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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