Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon.
CONCLUSION: The VK210 variant is the most frequently observed in the studied region and there is significant genetic variability in the CRR of the P. vivax CSP. Moreover, the antimalarial drug sensitivity profiles of the isolates does not seem to be related to the VK210 subtypes.
PMID: 31411308 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Pratt-Riccio LR, Baptista BO, Torres VR, Bianco-Junior C, Perce-Da-Silva DS, Riccio EKP, Lima-Junior JDC, Totino PRR, Cassiano GC, Storti-Melo LM, Machado RLD, de Oliveira-Ferreira J, Banic DM, Carvalho LJM, Daniel-Ribeiro CT Tags: Mem Inst Oswaldo Cruz Source Type: research
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