Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells.

CONCLUSIONS: Our findings suggest that variability in virulence among Mtb clinical strains affects the capacity of DCs to respond to pathogenic challenge and mount an immune response against it, highlighting important parallels to studies previously done in mouse models.
PMID: 31411311 [PubMed - in process]

Source: Memorias do Instituto Oswaldo Cruz - August 16, 2019 Category: Infectious Diseases Authors: Ramos-Martinez AG, Valtierra-Alvarado MA, Garcia-Hernandez MH, Hernandez-Pando R, Castañeda-Delgado JE, Cougoule C, Rivas-Santiago B, Neyrolles O, Enciso-Moreno JA, Lugo-Villarino G, Serrano CJ Tags: Mem Inst Oswaldo Cruz Source Type: research