[Medicinal Complex Therapy - Drug Interaction of Valproate and Dipyrone].

[Medicinal Complex Therapy - Drug Interaction of Valproate and Dipyrone]. Psychiatr Prax. 2019 Aug 14;: Authors: Kliem A, Green K, Mattern M Abstract The clinical relevance of the drug interaction between valproic acid and dipyrone is presented in the context of a gerontopsychiatric case. It is assumed that dipyrone at a dose of 4 g/d has a relevant influence on the valproate level and the associated clinical outcome. This may be due to a possible induction of CYP2B6 and increased valproate metabolism. In the case of a treatment of valproate combined with dipyrone, a close monitoring of the valproate level is recommended. PMID: 31412367 [PubMed - as supplied by publisher]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research
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