The folate pathway inhibitor pemetrexed pleiotropically enhances effects of cancer immunotherapy.

CONCLUSIONS: Pemetrexed augments systemic intra-tumor immune responses through tumor intrinsic mechanisms including immunogenic cell death, T cell-intrinsic mechanisms enhancing mitochondrial biogenesis leading to increased T cell infiltration/activation along with modulation of innate immune pathways, significantly enhanced in combination with PD-1 pathway blockade.
PMID: 31409612 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - August 12, 2019 Category: Cancer & Oncology Authors: Schaer DA, Geeganage S, Amaladas N, Lu ZH, Rasmussen ER, Sonyi A, Chin D, Capen A, Li Y, Meyer CM, Jones BD, Huang X, Luo S, Carpenito C, Roth KD, Nikolayev A, Tan B, Brahmachary M, Chodavarapu K, Dorsey FC, Manro JR, Doman TN, Donoho GP, Surguladze D, Ha Tags: Clin Cancer Res Source Type: research