Medical care for migrant children in Europe: a practical recommendation for first and follow-up appointments
Conclusion: The current document includes general recommendations on ethical standards, use of interpreters and specific recommendations for prevention or early detection of communicable and non-communicable diseases. It may serve as a tool to ensure the fundamental right that migrant children in Europe receive a comprehensive, patient-centred health care.
Publication date: Available online 23 January 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Jun Zhang, Tao Huang, Wen-Tao Chen, Jie-Yi Yang, Yao-Hua Xue, Ying-ping Xu, He-Ping Zheng
In this study, we show upregulation of PfGCN5 upon nutrient stress condition. With the help of chromatin immunoprecipitation coupled high-throughput sequencing (ChIP-seq) and transcriptomic (RNA-sequencing) analyses, we show that PfGCN5 is associated with the genes that are important for the maintenance of parasite cellular homeostasis upon nutrient stress condition. Furthermore, we identified various metabolic enzymes as interacting partners of PfGCN5 by immunoprecipitation coupled with mass spectroscopy, possibly acting as a sensor of nutrient conditions in the environment. We also demonstrated that PfGCN5 interacts and ...
Authors: Bouchaud O, Bruneel F, Caumes E, Houzé S, Imbert P, Pradines B, Rapp C, Strady C PMID: 31964565 [PubMed - as supplied by publisher]
CONCLUSION: The diagnosis of PIGCH remains clinically challenging and requires a high index of suspicion as well as a thorough history, physical examination, serological workup and liver biopsy. Treatment of the underlying cause can result in clinical stability in a large number of cases. PMID: 31966907 [PubMed]
CONCLUSIONS: Dpcr greatly improved the sensitivity and specificity of cccDNA detection. Host CDK activities are likely required for cccDNA synthesis. dPCR can potentially be applied for drug screening for effective cccDNA inhibitors. PMID: 31964596 [PubMed - as supplied by publisher]
ConclusionsThis retrospective study showed that TARE therapy resulted in minimal toxicity in patients with HBV-derived HCC. Patients with CP A or BCLC A disease had superior survival outcomes compared to patients with CP B and BCLC B/C disease. These findings suggest that TARE is a viable treatment option for certain patient groups with HCC tumors secondary to HBV infection.
Publication date: February 2020Source: Journal of Functional Foods, Volume 65Author(s): Yueliang Zhao, Mengru Tao, Ru Wang, Yuanqiang Guo, Mingfu WangAbstractHepatitis E virus (HEV) is one of the major causes of acute hepatitis worldwide. Here, we investigated the role of autophagy on HEV replication and demonstrated anti-HEV effects of japonicone V, a main constituent of the flowers of Inula japonica. Results showed that HEV infection induced autophagy in Huh7 cells. Chloroquine (CQ) and 3-methyladenine (3-MA), two autophagy inhibitors inhibited HEV replication. Moreover, japonicone V suppressed HEV replication and inhibi...
Publication date: 25–31 January 2020Source: The Lancet, Volume 395, Issue 10220Author(s): Peter Gething, Simon Hay, Daniel Weiss
Publication date: 25–31 January 2020Source: The Lancet, Volume 395, Issue 10220Author(s): Freya J I Fowkes, Eliza Davidson, Kerryn A Moore, Rose McGready, Julie A Simpson
Fanconi anemia (FA) is a rare genetic disorder characterized by defective cellular DNA repair, associated developmental abnormalities, progressive bone marrow failure (BMF), and a predisposition to hematologic malignancies and solid tumors. 80% of FA patients develop BMF due to progressive depletion of their BM stem cells. Although allogeneic HSCT is a curative treatment for BMF, its utilization and efficacy is limited by availability of donors, risk of GVHD and transplant-related toxicities. Pre-clinical studies showed that ex-vivo insertion of a functional FANCA gene into autologous FA-A CD34+ HSPCs provides a survival a...