New drug may speed blood recovery after chemotherapy

A new drug may help to speed up the rejuvenation of blood stem cells after chemotherapy, a new study says.
Source: Health News - - Category: Consumer Health News Source Type: news

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Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Crescenzo D’Alterio, Stefania Scala, Gabriella Sozzi, Luca Roz, Giulia BertoliniAbstractSeveral lines of compelling pre-clinical evidence identify chemotherapy as a potentially double-edged sword: therapeutic efficacy on the primary tumor may in fact be counterbalanced by the induction of tumor/host reactive responses supportive for survival and dissemination of cancer cell subpopulations. This paradoxical effect of chemotherapy can affect different districts such as the primary tumor, the circulation and distant organs by s...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
AbstractBiosimilar filgrastim (Sandoz) was approved in Europe in 2009 and, in 2015, was the first biosimilar approved in the USA. These authorizations were based on the “totality of evidence” concept, an approach that considers data from structural and functional characterization and comparability analysis and non-clinical and clinical studies. For biosimilar filgrastim, phase III confirmatory clinical studies were performed in the most sensitive population, pa tients with breast cancer undergoing myelosuppressive chemotherapy. In Europe and the USA, approval was granted for all indications of the reference bio...
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
This study highlights poor outcomes for patients with BPDCN in the modern era and the need for new treatments. Outcomes from ongoing clinical trials for BPDCN can be evaluated relative to this contemporary cohort.
Source: Blood - Category: Hematology Authors: Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
M, Nagler A Abstract Core binding factor acute myeloid leukemia comprises two subtypes with distinct cytogenetic abnormalities of either t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). Since long-term response to chemotherapy in those leukemias is relatively good, allogeneic hematopoietic stem cell transplantation is considered in patients who relapse and achieve second complete remission. To evaluate the outcomes of allogeneic transplantation in this indication, we studied 631 patients in reported to the European Society for Blood and Marrow Transplantation Registry between the years 2000 and 2014. Leukemi...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
A 48-year-old woman with a history of AIDS and stage IV Hodgkin lymphoma status post chemotherapy and stem cell transplant presented with 8 months of painful perineal erosions and exophytic plaques. Her medical history was significant for acyclovir-resistant herpes simplex virus (HSV) and multiple opportunistic infections. Examination revealed diffuse discontinuous eroded plaques in the perineum, and scattered skin-colored and hyperpigmented exophytic plaques with raised borders and central craters overlying the sacrum, gluteal cleft, and perineum.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
DiscussionThe observed resistance and functional integrity may form the basis for further investigations of MSCs as a potential therapy for antimetabolite-induced tissue damage.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Abstract Resistance to chemotherapy and relapse are major hurdles for the effective treatment of cancer. Major reason for this is a small sub population of cancer stem cells (CSCs) and its microenvironment. CSCs are critical driving force for several types of cancer such as gastric, colon, breast and many more. Hence, for the complete eradication of cancer, it is necessary to develop therapeutic approaches that can specifically target CSCs. Chemical agents that target different proteins involved in CSC signaling pathways, either as single agent or parallelly targeting two or more proteins have generated promising ...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research
ConclusionOur research suggests the experimental evidence for DFO and CDDP as a new effective combination therapy to enhance the efficacy of chemical therapy in ovarian cancer.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
X-linked agammaglobulinemia (XLA), caused by a mutation in the Bruton’s tyrosine kinase (BTK) gene, is rarely reported in patients with recurrent hemophagocytic lymphohistiocytosis (HLH). This mutation leads to significantly reduced numbers of circulatory B cells and serum immunoglobulins in patients. Therefore, they exhibit repetitive bacterial infections since infancy, and immunoglobulin (Ig) replacement therapy is the primary treatment. HLH is a life-threatening condition with manifestations of nonremitting fever, hepatosplenomegaly, cytopenias, coagulopathy, lipid disorder, and multiple organ failure. It is cause...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the prognosis of these brain tumors is still very poor. Glioblastomas contain a population of glioma stem cells (GSCs), with self-renewal ability, which are partly responsible for the tumor resistance to therapy and for the tumor recurrence after treatments. The human adult subventricular zone contains astrocyte-like neural stem cells (NSCs) that are probably reminiscent of the radial glia present in embryonic b...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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