Newly-discovered ORGAN in skin causes us to feel pain

Scientists from the Karolinska Institute in Sweden discovered a mesh-like organ within the skin that consists of glial cells. These cells have hair-like structures that may pick up on pain.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 24 August 2019Source: Neuroscience LettersAuthor(s): Deva Sharma, Amanda M. BrandowAbstractPain is the most frequently occurring complication of sickle cell disease (SCD) and the leading cause of hospitalizations for affected individuals. Acute pain episodes are also an independent predictor of mortality in individuals with SCD. The pathophysiology of pain in SCD is complex and has been attributed to several biologic factors, including oxidative stress, vaso-occlusion, ischemia-reperfusion injury and inflammation. In spite of this complex biology, painful events requiring hospitalization ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
I don't remember what it feels like to live without pain. At 15, I began feeling aching, stabbing, and burning sensations in my lower back and down my legs. Swallowing a few Aleve didn't help —in fact, nothing did. If I sit or stand for any period of time, or lift something heavy or fall, I pay for it, sometimes for weeks or months. I've slept on the kitchen linoleum, because the carpet felt too soft to stand.For 17 years, I went to doctor after doctor, undergoing scans, physical therapy, and just about every"alternative" treatment that promised relief. Despite some amazing doctors and the expen...
Source: Psychology of Pain - Category: Anesthesiology Source Type: blogs
Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study The purpose of this study was to compare the efficacy and safety of curcumin with those of diclofenac in the treatment of knee osteoarthritis (OA). In this randomized, open-label, parallel, active controlled clinical study, 139 patients with knee OA were randomly assigned to receive either a... trialsjournal.biomedcentral.com Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Cu...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Abstract Every age group experiences back pain, a common reason for activity limitation. Management of back pain in a woman is challenging because of physiologic and hormonal changes through the woman's life cycle. The treatment is dictated by etiology and a woman's stage of life or reproductive events, such as pregnancy, breastfeeding, and menopause. Most episodes of low back pain are temporary with minimal long-term sequelae, but recurrent and long-lasting episodes require more thorough clinical evaluation. This monograph describes the anatomy of the spine; illustrates a focused, thorough evaluation, including o...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
ConclusionOnly a few cases of penile FG have been reported. Early debridement of all necrotic tissue is the golden rule.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present an unusual case of a large dumb-bell-shaped cold abscess arising due to infection of the sternum. A 23-year-old immunocompetent Asian woman presented with a gradually progressing painless swelling on anterior chest wall for the last 5  months. She had a large visible swelling on anterior chest wall which was 12.5 cm in diameter, soft, non-tender, temperature was not raised, and fluctuant. Magnetic resonance imaging showed a large dumb-bell-shaped hyperintense collection in upper anterior chest wall with marrow edema and corti cal irregularity in left side of manubrium. Pus was positive for nucleic ...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
We report a case of 16 year old male, who was presented to Jawaharlal Nehru Medical College, AMU, Aligarh, India as an emergency case with complaints of severe abdominal pain, difficulty in breathing and bilious vomiting. He was diagnosed as a case of late post traumatic right side diaphragmatic hernia with acute intestinal obstruction. He was successfully treated surgically by laparotomy and the defect was closed with polypropylene suture. The patient was followed for 3 months after operation and there was no complication. PMID: 31435467 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Conclusions: No safety concerns were identified from this retrospective EHR review of hospitalized adults who received a milk and molasses enema for constipation relief. The findings indicate that this treatment is safe, although further study examining its efficacy in this population is needed.
Source: AJN - Category: Nursing Tags: Feature Articles Source Type: research
Abstract Ischemic colitis primarily affects the elderly with underlying disease, but it rarely occurs in young adults with risk factors, such as coagulopathy or vascular disorder. Moreover, it is extremely rare in the very young without risk factors. This paper presents a patient with ischemic colitis associated with heat stroke and rhabdomyolysis after intense exercise under high-temperature conditions. A 20-year-old man presented with mental deterioration after a vigorous soccer game for more than 30 minutes in sweltering weather. He also presented with hematochezia with abdominal pain. The laboratory tests reve...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
Abstract Pancreatic cancer is a dismal disease with a poor prognosis and is one of the most painful malignancies. Therefore, adequate pain control is essential to improving the patient's quality of life. Pain in pancreatic cancer has complex pathophysiologic mechanisms and different characteristics. The choice of pain management modalities should be individualized depending on the pain characteristics using a multidisciplinary approach. The treatment options available include medical treatment, chemotherapy, celiac plexus/ganglion neurolysis, radiotherapy, and endoscopic technique. This review discusses the medica...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
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