Gallstone sufferers may one day avoid surgery thanks to new discovery

Scientists from University Hospital Erlangen, Germany, discovered the 'established' beta-blocker metoprolol blocked the growth of gallstones in mice with the painful condition.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Medics in Nong Khai, Thailand - on the border of Laos - conducted a scan and found hundreds of gallstones inside her gallbladder. They spent 40 minutes removing the lumps.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
AbstractBackgroundEmergent laparoscopic transcystic common bile duct exploration (LTCBDE) has been reported to be on the increase in some institutions, reflecting the growing confidence with the technique. However, no study has focused on the outcomes of LTCBDE in the non-elective setting. The aim of this study is to investigate whether LTCBDE can be performed effectively and safely in the emergency.MethodsThis is a retrospective study of 500 consecutive patients with choledocholithiasis subjected for LTCBDE at the Hospital Italiano de Buenos Aires from January 2009 to January 2018. Procedures were classified according to ...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
ConclusionsSurgeons have recently embraced POCUS to expedite diagnosis of AC and provide rapid decision-making and early treatment, streamlining the patient pathway and thereby reducing costs and morbidity.
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
AbstractHyperbilirubinemia is a common occurrence in neonates; it may be physiological or pathological. Conjugated hyperbilirubinemia may result from medical or surgical causes, and can result in irreversible liver damage if untreated. The aim of imaging is the timely diagnosis of surgical conditions like biliary atresia and choledochal cysts. Abdominal ultrasound is the first line imaging modality, and Magnetic resonance cholangiopancreatography (MRCP) also has a role, especially in pre-operative assessment of choledochal cysts (CDCs). For biliary atresia, the triangular cord sign and gallbladder abnormalities are the two...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
We present the case of a patient with heterotaxic anatomy and partial situs inversus with acute cholecystitis. PMID: 31418295 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
Introduction: Early cholecystectomy shortly after admission for mild gallstone pancreatitis has been proposed based on observational data. We hypothesized that cholecystectomy within 24 hours of admission versus after clinical resolution of gallstone pancreatitis that is predicted to be mild results in decreased length-of-stay (LOS) without an increase in complications. Methods: Adults with predicted mild gallstone pancreatitis were randomized to cholecystectomy with cholangiogram within 24 hours of presentation (early group) versus after clinical resolution (control) based on abdominal exam and normalized laborat...
Source: Annals of Surgery - Category: Surgery Tags: PAPERS OF THE 139TH ASA ANNUAL MEETING Source Type: research
Nature, Published online: 15 August 2019; doi:10.1038/d41586-019-02449-zImmune cell extrudes a webbing that can encourage the growth of gallstones, a common and painful malady.
Source: Nature AOP - Category: Research Source Type: research
Immune cells may help painful gallstones grow by ejecting sticky nets of DNA around the crystals that form in bile – a finding that could lead to new treatments
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Cholelithiasis, the presence of gallstones in the gallbladder or ducts, is a prevalent human disease with a high socioeconomic burden. Mu ñoz and colleagues demonstrate that the formation of neutrophil extracellular traps fosters the generation and growth of gallstones.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Report Source Type: research
The objective of this study was to determine whether ICP is associated with specific long ‐term comorbidity.Material and methodsThe study population comprised 571 women with ICP in at least one pregnancy who were compared with 1333 pregnant women without ICP during 1969 ‐1988 at Tampere University Hospital, Finland. The cohort's follow‐up time was 44 years. All ICD‐10 classification discharge diagnoses were examined for the women in the ICP group from 1998 to 2013 and ICD‐10 diagnoses from outpatient care from 1969 to 2013.ResultsAt least one disease of the digestive system had been diagnosed in 50.4% (288/5...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
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