A β-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

AbstractExtracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) represent pathological hallmark lesions of Alzheimer’s disease (AD). Both lesions develop in parallel in the human brain throughout the preclinical an d clinical course of AD. Nevertheless, it is not yet clear whether there is a direct link between Aβ and τ pathology or whether other proteins are involved in this process. To address this question, we crossed amyloid precursor protein (APP) transgenic mice overexpressing human APP with the Swedis h mutation (670/671 KM → NL) (APP23), human wild-type APP (APP51/16), or a proenkephalin signal peptide linked to human Aβ42 (APP48) with τ-transgenic mice overexpressing human mutant 4-repeat τ-protein with the P301S mutation (TAU58). In 6-month-old APP23xTAU58 and APP51/16xTAU58 mice, soluble Aβ was associated with the aggravation of p-τ pathology propagation into the CA1/subiculum region, whereas 6-month-old TAU58 and APP48xTAU 58 mice neither exhibited significant amounts of p-τ pathology in the CA1/subiculum region nor displayed significant levels of soluble Aβ in the forebrain. In APP23xTAU58 and APP51/16xTAU58 mice showing an acceleration of p-τ propagation, Aβ and p-τ were co-immunoprecipitated with cellular prio n protein (PrPC). A similar interac...
Source: Acta Neuropathologica - Category: Neurology Source Type: research

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Abstract Pharmaceuticals which originally were designed to treat people with neurological and psychiatric conditions, e.g. Alzheimer's disease or attention deficit hyperactivity disorder (ADHD), are nowadays often misused by students as a 'brain doping' substances. These substances are known as nootropic drugs, smart drugs or cognitive enhancers, as they increase memory, attention and concentration of healthy individuals. Since they are easily available illicitly, their consumption is observed to be growing. Currently, these pharmaceuticals started gaining researchers' attention, especially since they have been re...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Edward Stopa, MD,65, after a brief and courageous battle with pancreatic cancer. He touched many lives and served as mentor to many in neuropathology, including me. Since 1993, Ed was the director of neuropathology at Brown and led the division until his retirement earlier this year. I was a neuropathology fellow under his directorship from 2004-06 and fondly remember his sense of humor, curiosity, andjoie de vivre.Ed made many strides in the understanding of Alzheimer disease through close collaborations with basic and clinical neuroscientists. He contributed extensively to our knowledge of the hypothalamic mechanisms tha...
Source: neuropathology blog - Category: Radiology Tags: neuropathologists Source Type: blogs
Authors: Mohd Sahardi NFN, Makpol S Abstract Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer's disease (AD), Parkinson's disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases. In general, oxidative stress could induce proinflammatory cytokines ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Neurology, Psychiatry, Geriatrics, Sports Medicine, News, Source Type: news
Aerobic exercise slows hippocampal atrophy and improves memory in some older patients at high risk for Alzheimer disease, but stretching also benefits the brain.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Psychiatry News Source Type: news
Conditions:   Blood Brain Barrier Defect;   Sleep Deprivation;   Sleep Apnea;   Alzheimer Disease Intervention:   Diagnostic Test: Diagnostic Test Sponsors:   Charite University, Berlin, Germany;   Arda Can Cetindag;   Lukas Preis Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Results of a large population-based cohort study support regulatory agency warnings about the risk for donepezil-induced rhabdomyolysis, a rare but potentially life-threatening condition.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Psychiatry News Source Type: news
In clinical practice “Doctor, do I have dementia?” is an increasingly common question, but one that is often difficult to answer.  Accurate diagnosis is the first step in managing someone with cognitive concerns. Early diagnosis of a cognitive syndrome, if present, can allow people to make sense of their symptoms, and can help people plan their future, while allowing access to treatments and support.To mark World Alzheimer's Day on September 21, theCochrane Dementia and Cognitive Improvement Group have brought together all the completed test accuracy reviews focusing on cognitive screening tests and questi...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Publication date: September 2019Source: Alzheimer's &Dementia, Volume 15, Issue 9Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: September 2019Source: Alzheimer's &Dementia, Volume 15, Issue 9Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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