Electrophysiological Characterization of a Small Molecule Activator on Human Ether-a-go-go-Related Gene (hERG) Potassium Channel

In conclusion, we identified a novel hERG channel activator HW-0168 that can be used for studying the physiological role of hERG in cardiac myocytes and may be beneficial for treating long QT syndrome.
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 1 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Florina Zakany, Tamas Kovacs, Gyorgy Panyi, Zoltan Varga
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
This study is consistent with other research, as well as with reports from physicians who recommend cannabis in their daily practices. What might be behind this trend? A confluence of factors seems to be responsible, including the decrease in stigma associated with cannabis use and the increased interest in the use of medical marijuana by older patients. Stigma is a complicated issue, but most would agree that the stigma associated with cannabis use is lessening, especially for medical cannabis. In a recent poll, 94% of Americans voiced support for legal access to medical marijuana, and most states have approved some form ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Aging Marijuana Pain Management Source Type: blogs
Purpose of review Physical inactivity is common in hemodialysis patients, and is associated with disability and poor outcomes. We summarize the effects of aerobic, resistance or mixed exercise training on aerobic capacity, muscle mass and strength, dialysis efficiency, quality of life and cardiovascular adaptation according to clinical studies on this population, also focusing on knowledge gaps as topics for future research. Finally, we put evidence into clinical context deriving practical indications for exercise implementation in these patients. Recent findings In hemodialysis patients, aerobic or mixed exercise tra...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: TRANSLATIONAL RESEARCH IN WASTING DISEASES: Edited by Claude Pichard and Mariëlle P.K.J. Engelen Source Type: research
Source: Sensor Letters - Category: Medical Devices Authors: Tags: Research Articles Source Type: research
Invasive diagnostic test for cardiac arrhythmia – MCQ Invasive diagnostic test used in the assessment of cardiac arrhythmia: a) Coronary angiography b) Ambulatory ECG c) Electrophysiology study d) Swan-Ganz catheterization Post your answer as a comment below
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
Publication date: Available online 31 March 2020Source: Materials LettersAuthor(s): Jieyi Chen, Honglie Shen, Zihao Zhai, Fei Liu, Zhipeng Zhu, Minghao Luo
Source: Materials Letters - Category: Materials Science Source Type: research
The Journal of Organic ChemistryDOI: 10.1021/acs.joc.9b03272
Source: The Journal of Organic Chemistry - Category: Chemistry Authors: Source Type: research
Common indication for echocardiography – MCQ – Answer Which of the following is not a common indication for echocardiography? – Correct answer: d) Analysis of cardiac arrhythmia Analysis of cardiac arrhythmia is better done using an ECG. In patients with cardiac arrhythmia, echocardiography is useful in looking for underlying structural heart disease. Echocardiography can be used to assess arrhythmias in fetus when ECG is not feasible. But it is not very accurate and is quite cumbersome, time consuming process. Back to question
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
AbstractLong QT syndrome (LQTS) is an inherited primary arrhythmia syndrome that may present with malignant arrhythmia and, rarely, risk of sudden death. The clinical symptoms include palpitations, syncope, and anoxic seizures secondary to ventricular arrhythmia, classicallytorsade de pointes. This predisposition to malignant arrhythmia is from a cardiac ion channelopathy that results in delayed repolarization of the cardiomyocyte action potential. The QT interval on the surface electrocardiogram is a summation of the individual cellular ventricular action potential durations, and hence is a surrogate marker of the abnorma...
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 18 May 2017 Source:Pharmacology & Therapeutics Author(s): Isik Turker, Tomohiko Ai, Hideki Itoh, Minoru Horie Since the early 1990s, the concept of primary “inherited” arrhythmia syndromes or ion channelopathies has evolved rapidly as a result of revolutionary progresses made in molecular genetics. Alterations in genes coding for membrane proteins such as ion channels or their associated proteins responsible for the generation of cardiac action potentials (AP) have been shown to cause specific malfunctions which eventually lead to cardiac arrhythmias. These arrhythmic dis...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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