Long noncoding RNA NORAD regulates MPP+-induced Parkinson’s disease model cells

ConclusionWe presented a novel functional role of lncRNA NORAD in regulating human Parkinson’s disease.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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α-Synuclein Overexpression Induces Lysosomal Dysfunction and Autophagy Impairment in Human Neuroblastoma SH-SY5Y. Neurochem Res. 2020 Sep 11;: Authors: Nascimento AC, Erustes AG, Reckziegel P, Bincoletto C, Ureshino RP, Pereira GJS, Smaili SS Abstract Although the etiology of Parkinson's disease (PD) is multifactorial, it has been linked to abnormal accumulation of α-synuclein (α-syn) in dopaminergic neurons, which could lead to dysfunctions on intracellular organelles, with potential neurodegeneration. Patients with familial early-onset PD frequently present mutation in the α-...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research
AbstractMild hypothermia has promising effects in the treatment of acute brain insults and also affects cell cycle progression. Mitochondrial dynamics, fusion and fission, are changed along with the cell cycle and disrupted in neurodegenerative diseases, including Parkinson ’s disease (PD). However, the effects of hypothermia on aberrant mitochondrial dynamics in PD remain unknown. We hypothesized that mild hypothermia protects neurons by regulating cell cycle-dependent protein expression and mitochondrial dynamics in a 1-methyl-4-phenylpyridinium (MPP+)-induced cell model of PD. We found that the hypothermia treatme...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Naphthoquinone-Dopamine hybrids inhibit α-synuclein aggregation, disrupt preformed fibrils and attenuate aggregate-induced toxicity. Chemistry. 2020 Sep 01;: Authors: Paul A, Huber A, Rand D, Gosselet F, Cooper I, Gazit E, Segal D Abstract Accumulation and aggregation of the intrinsically disordered protein α-synuclein (α-Syn) into amyloid fibrils are hallmarks of a series of heterogeneous neurodegenerative disorders, known as synucleinopathies and most notably Parkinson's disease (PD). The crucial role of α-Syn aggregation in PD makes it an attractive target for the devel...
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research
AbstractA major pathological feature of Parkinson ’s disease (PD) is the aberrant accumulation of misfolded assemblies of alpha‐synuclein (α‐Syn). Protein clearance appears as a regulator of the ‘’α‐Syn burden” underlying PD pathogenesis. The picture emerging is that a combination of pathways with complementary roles, including the Proteasome System and the Autophagy‐Lysosome Pathway, contributes to the intracellular degradation ofα‐Syn. The current study addresses the mechanisms governing the degradation ofα‐Syn species seeded by exogenous fibrils in neuronally d...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Mitochondrial dysfunction is considered to be one of the important pathogenesis in Parkinson's disease (PD). We previously showed that pyrroloquinoline quinone (PQQ) could protect SH-SY5Y cells and dopaminergic neurons from cytotoxicity and prevent mitochondrial dysfunction in rotenone-induced PD models. In the present study we investigated the mechanisms underlying the protective effects of PQQ in a mouse PD model, which was established by intraperitoneal injection of rotenone (3 mg·kg-1·d-1, ip) for 3 weeks. Meanwhile the mice were treated with PQQ (0.8, 4, 20 mg·kg-1&...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharmacol Sin Source Type: research
In conclusion, our in vitro data suggests that nN OS and uPA may serve as viable candidate biomarkers of acute and chronic neuroinflammation.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
oz-Soriano V, Paricio N Abstract Parkinson's disease (PD) is a neurodegenerative debilitating disorder characterized by progressive disturbances in motor, autonomic and psychiatric functions. One of the genes involved in familial forms of the disease is DJ-1, whose mutations cause early-onset PD. Besides, it has been shown that an over-oxidized and inactive form of the DJ-1 protein is found in brains of sporadic PD patients. Interestingly, the DJ-1 protein plays an important role in cellular defense against oxidative stress and also participates in mitochondrial homeostasis. Valuable insights into potential PD pat...
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Publication date: Available online 20 July 2020Source: Molecular Aspects of MedicineAuthor(s): Meric A. Altinoz, İlhan Elmaci, Ahmet Hacimuftuoglu, Alp Ozpinar, Emily Hacker, Aysel Ozpinar
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
This study afforded the clear elaboration on the PD pathomechanism concerning NORAD.
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
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