What Is the Best Target for Ablation of Mesial Temporal Lobe Epilepsy?

What Is the Best Target for Ablation of Mesial Temporal Lobe Epilepsy? Epilepsy Curr. 2019 Aug 13;:1535759719868460 Authors: King-Stephens D Abstract Effects of Surgical Targeting in Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy: A Multicenter Study of 234 Patients Wu C, Jermakowicz WJ, Chakravorti S, Cajigas I, Sharan AD, Jagid JR, Matias CM, Sperling MR, Buckley R, Ko A, Ojemann JG, Miller JW, Youngerman B, Sheth SA, McKhann GM, Laxton AW, Couture DE, Popli GS, Smith A, Mehta AD, Ho AL, Halpern CH, Englot DJ, Neimat JS, Konrad PE, Neal E, Vale FL, Holloway KL, Air EL, Schwalb J, Dawant BM, D'Haese PF. Epilepsia. 2019;60(6):1171-1183. doi:10.1111/epi.15565. OBJECTIVE: Laser interstitial thermal therapy (LITT) for mesial temporal lobe epilepsy (mTLE) has reported seizure freedom rates between 36% and 78%, with at least 1 year of follow-up. Unfortunately, the lack of robust methods capable of incorporating the inherent variability of patient anatomy, the variability of the ablated volumes, and clinical outcomes have limited 3-dimensional quantitative analysis of surgical targeting and its impact on seizure outcomes. We therefore aimed to leverage a novel image-based methodology for normalizing surgical therapies across a large multicenter cohort to quantify the effects of surgical targeting on seizure outcomes in LITT for mTLE. METHODS: This multicenter, retrospective cohort study included 234 pa...
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research