The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation.

The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation.
Arch Biochem Biophys. 2019 Aug 09;:108069
Authors: Duncan D, Auclair K
Abstract
Prodrugs account for more than 5% of pharmaceuticals approved worldwide. Over the past decades several prodrug design strategies have been firmly established; however, only a few functional groups remain amenable to this approach. The aim of this overview is to highlight the use of coenzyme A (CoA) biosynthetic enzymes as a recently explored bioactivation scheme and provide information about its scope of utility. This emerging tool is likely to have a strong impact on future medicinal and biological studies as it offers promiscuity, orthogonal selectivity, and the capability of assembling exceptionally large molecules.
PMID: 31404525 [PubMed - as supplied by publisher]

Source: Archives of Biochemistry and Biophysics - August 8, 2019 Category: Biochemistry Authors: Duncan D, Auclair K Tags: Arch Biochem Biophys Source Type: research