PT02.4: Assessing Skeletal Muscle Mass with Ultrasound in Patients with Systemic Sclerosis

Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Geriatrics/Nutrition and chronic disease/Nutritional epidemiology Source Type: research

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The objective of the study was to investigate how serum levels of YKL-40 and IL-6 correlate with articular and periarticular involvement in patients with SSc assessed by high-frequency ultrasonography. 59 SSc patients (56 women, 3 men) and 23 age-matched healthy subjects (21 women and 2 men) were investigated for serum YKL-40 and IL-6 (by ELISA). All the patients and healthy controls underwent clinically and high-frequency ultrasound assessment of articular and periarticular structures. Joint involvement was scored according to the new US10SSc score. Clinical data about the SSc patients showed significantly higher mRSS in ...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractLung ultrasound (LUS) correlates with chest high-resolution computed tomography (HRCT) findings in the diagnosis of interstitial lung disease (ILD) in systemic sclerosis (SSc). The aim of this study is to evaluate the predictive value of LUS in the progression of ILD. At baseline, forty-one SSc patients underwent HRCT, LUS for detection of B-lines, and pulmonary function test (PFTs). PFTs were performed also after 12  months to evaluate pulmonary function deterioration. In multiple regression analysis, positive correlation exists between the number of B-lines and HRCT score (r = 0.51,p 
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusions:Sonoelastography could be used for evaluating skin of forearm insclerodermic cases which will be helpful for disease evaluation in clinical course.Keywords:Elasticity imaging techniques, scleroderma, skin
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
CONCLUSION: In conclusion, in spite of a great deal of work supporting the potential role of LUS for the assessment of ILD-SSc too much remains to be done to validate its use as an outcome measure in ILD-SSc. PMID: 31263075 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Lung diffusing capacity for nitric oxide may be of clinical value in systemic sclerosis because more sensitive to interstitial lung disease than standard lung diffusing capacity for carbon monoxide. AbstractA decreased lung diffusing capacity for carbon monoxide (DLCO) in systemic sclerosis (SSc) is considered to reflect losses of alveolar membrane diffusive conductance for CO (DMCO), due to interstitial lung disease, and/or pulmonary capillary blood volume (VC), due to vasculopathy. However, standard DLCO does not allow separate DMCO from VC. Lung diffusing capacity for nitric oxide (DLNO) is considered to be more sensiti...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
Abstract OBJECTIVE: Renal involvement in systemic sclerosis (SSc) range from urinary abnormalities, reduction of glomerular filtrate rate (GFR), high renal resistive index to scleroderma renal crisis (SCR). Intrarenal resistance indices are considered markers of renal scleroderma-associated vasculopathy. The aim of this study is to evaluate renal morphological parameters, such as renal length, parenchymal thickness, atrophy index, renal sinus in SSc patients and to correlate it with renal function and hemodynamic parameters. METHODS: Ninety-two SSc patients and forty healthy controls (HC) were enrolled in thi...
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
The objective is to detect any possible correlation between the modified Rodnan skin score (mRSS) and dermal thickness (DT) measured by skin high-frequency ultrasound (US) and the percentage of circulating fibrocytes in patients with limited cutaneous systemic sclerosis (lcSSc). Eight lcSSc patients and five healthy subjects (control group, CNT) were enrolled. The skin involvement was evaluated by mRSS and US (18 and 22  MHz probes) in all 13 subjects in the 17 standard skin areas evaluated by mRss. Circulating fibrocytes were isolated from the peripheral blood mononuclear cells (PBMCs) of all lcSSc patients and the C...
Source: Rheumatology International - Category: Rheumatology Source Type: research
In this study, we analyzed the metabolic profiling of fecal samples from SLE patients and healthy controls based on ultra-high-performance liquid chromatography equipped with mass spectrometry for exploring the potential biomarkers of SLE. The results showed that 23 differential metabolites and 5 perturbed pathways were identified between the two groups, including aminoacyl-tRNA biosynthesis, thiamine metabolism, nitrogen metabolism, tryptophan metabolism, and cyanoamino acid metabolism. In addition, logistic regression and ROC analysis were used to establish a diagnostic model for distinguishing SLE patients from healthy ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractPurpose of the ReviewNovel imaging approaches, such as quantitative computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging, are being applied to interstitial lung diseases to provide prognostic, functional, and molecular information. Here, we review such imaging approaches and their applicability to systemic sclerosis-associated interstitial lung disease (SSc-ILD).Recent FindingsQuantitative CT can be used to quantify the radiographic response to SSc-ILD therapy. Due to advances in MRI sequence development, MRI can detect the presence of SSc-ILD with high accuracy. MRI can also be utilize...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Conclusion: Significant differences of surface wave speed were found between ILD patients and healthy control subjects for both the lung and skin. Significance: LUSWE may be useful for assessing ILD and SSc and screening early stage patients.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
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