Scientists Discover New Cure for the Deadliest Strain of Tuberculosis

Once, a diagnosis of extensively drug-resistant TB meant quick death. A three-drug regimen cures most patients in just months.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Tuberculosis Clinical Trials Antibiotics Drugs (Pharmaceuticals) Drug Resistance (Microbial) Epidemics Food and Drug Administration TB Alliance World Health Organization Africa Johannesburg (South Africa) Pretoria (South Africa) Un Source Type: news

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ConclusionThe results suggested that Xanthine, 4-Pyridoxate, and d-glutamic acid may serve as potential biomarkers for pulmonary TB. The present study provides experimental basis for developing potential biomarkers of pulmonary TB.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Conclusion: Neurological disorders are common in HIV in Africa and the main CNS opportunistic infections result in high  mortality rates. Strategies aimed at reducing their high burden, morbidity and mortality include early HIV diagnosis and anti-retroviral therapy (ART), screening and chemoprophylaxis of main opportunistic infections, improved clinical diagnosis and management and programme strengthening.Keywords: Neurological disorders, HIV, Africa, opportunistic infections, direct HIV infection and inflammatory disorders.
Source: African Health Sciences - Category: African Health Source Type: research
[Premium Times] British-Nigerian-American actor, David Oyelowo, has joined other global artistes and athletes to sign an open letter to seven-year- olds, promising to end AIDS, tuberculosis and malaria as epidemics by 2030 - the year the children will become adults.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In this study, we provide for the first time a systematic investigation on the tropism, replication kinetics and pathogenesis of IBVs in the human respiratory tract. Physiologically relevant ex vivo explant cultures of human bronchus and lung, human airway organoids, and in vitro cultures of differentiated primary human bronchial epithelial cells and type-I-like alveolar epithelial cells were used to study the cellular and tissue tropism, replication competence and induced innate immune response of 16 IBV strains isolated from 1940 to 2012 in comparison with human seasonal influenza A viruses (IAVs), H1N1 and H3N2. IBVs fr...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung biology and experimental studies, Respiratory infections and tuberculosis Original Articles: Basic science and infection Source Type: research
ier F Abstract The development of combination antiretroviral therapies (cART) in the mid-nineties has dramatically modified the clinical presentation of critically ill HIV-infected patients. Most of cART-treated patients ageing with controlled HIV replication are nowadays admitted to the intensive care unit (ICU) for non-AIDS-related events, mostly bacterial pneumonia and exacerbation of comorbidities, variably impacted by chronic HIV infection - e.g., chronic obstructive pulmonary disease, cardiovascular diseases, or solid neoplasms. Today, Pneumocystis jirovecii pneumonia, cerebral toxoplasmosis, tuberculosis an...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
This report describes the case of a 9-year-old male patient who was suspected of having multidrug-resistant (MDR) tuberculosis, based on failure to recover clinically and radiologically after 6 months on first-line anti-tuberculosis treatment. Pus samples were sent to an accredited academic laboratory for histopathology, microscopy, culture, line-probe assay (MTBDRplus assay) and phenotypic MGIT 960 drug susceptibility tests. Second-line MDR tuberculosis treatment was introduced. Clinical, radiological, physical processes and more laboratory tests were conducted to document whether or not there was improvement in the patie...
Source: Topics in HIV Medicine - Category: Infectious Diseases Authors: Tags: Afr J Lab Med Source Type: research
Abstract The consumption of tonnes of anti-tubercular and other anti-microbial compounds for the control of the tuberculosis epidemic and other opportunistic diseases associated with human immunodeficiency virus presents tuberculosis-endemic countries such as South Africa, with a problem regarding the occurrence and fate of these compounds in the aquatic environment. The majority of these compounds are not readily degradable and could persist in the aquatic environment with potential detrimental effect on the aquatic microbiota ecosystem, development and dissemination of anti-microbial resistance as well as chroni...
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
By Jenny Dyer, Founder of the 2030 CollaborativeJuly 26, 2019Advocacy from the faith sector, particularly from the politically right-of-center voter, is now more crucial than ever.In March, the Trump Administration released its annual budget recommendations for Congress to consider for Appropriations, and for the third year in a row, this Administration recommended draconian cuts to the International Affairs Account, or our foreign assistance. For this sliver of an account representing a mere 1% of the entire U.S. budget, they recommended an overall cut of 24% to this account for FY20.In mid-May, the House Appropriations...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: Nutrition Leadership and Governance Policy & Advocacy SwitchPoint Source Type: news
Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: STATES OF THE ART Source Type: research
This study aimed to examine and compare the relevance between these three kinds of green space and incidences of the three types of epidemic diseases based on the Panel Data Model (PDM) with the time series data of 31 Chinese provinces from 2007 to 2016. The results indicated that there exists different, or even opposite, relevance between various kinds of green space and epidemic diseases, which might be associated with the process of urban sprawl in rapid urbanization in China. This paper provides a reference for re-thinking the indices of green space in building healthier and greener cities.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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