FDA approves tuberculosis drug that works on hard-to-treat cases
The FDA approved a new tuberculosis drug that improves treatment for the hardest-to-treat cases. Drug-resistant TB is a growing problem in many poor countries.
A Case of Bacteriologically Determined De NovoTuberculosis during Tumor Necrosis Factor-α Inhibitor Therapy. Intern Med. 2019 Aug 21;: Authors: Takahashi G, Kobayashi H, Saito Y, Ohsawa S, Suzuki K, Ishihara S, Hisada T Abstract A 58-year-old man with Crohn's disease received adalimumab for 13 months after screening results for tuberculosis were found to be negative. He was diagnosed with de novo mediastinal lymph-node tuberculosis, which was proved to be bacteriologically identical to that of an individual with smear positive lung tuberculosis by a variable number of tandem repeat analyses. Afte...
Australian researchers have successfully developed and tested a new type of vaccine targeting tuberculosis.
ABSTRACT: Introduction: The mortality rate among tuberculosis patients (TB fatality) has been attributed to irregular chemotherapy, delay in diagnosis, multidrug resistance, and HIV coinfection. Objective: To analyze TB fatality rates by sex, clinical presentation and HIV coinfection in Campinas, S ão Paulo, Brazil. Methods: Cohorts of residents in the city of Campinas who either died during treatment for tuberculosis or had the disease confirmed after death were divided into three intervals: 2001-2003, 2004-2006, and 2007-2009. Data were obtained from the database of the Tuberculosis Surve illance System of the Uni...
CONCLUSIONS: CLIA-IGRA is a reliable assay for LTBI diagnosis, with performance similar to that of QFT-GIT. PMID: 31432637 [PubMed - in process]
Kavitha Saravu, Madhukar PaiLung India 2019 36(5):373-375
Conclusions: MDR-TB can be cured successfully with modified DOTS-Plus strategy and requires much effort from both the patients and health-care workers. It can be an alternative model for treating MDR-TB patients in private sector.
. Singh In 2017, more than half of the global burden of incident tuberculosis (TB) came from the Western Pacific region. In Lao People’s Democratic Republic (PDR), the high rates of tobacco use and use of polluting biomass fuels for cooking (e.g., wood, charcoal, crop waste, dung) represent significant risk factors for TB. The purpose of this study was to determine the association between self-reported (1) smoking and TB; and (2) exposure to air pollution (from both cooking fires and environmental tobacco smoke) and TB among adults in Lao PDR. We analyzed data from the 2012 National Adult Tobacco Survey (NATS...
Disparities persist by race, ethnicity, geography; incidence higher for those living in U.S. - affiliated islands
Conditions: Tuberculosis; BCG Vaccination Interventions: Device: BCG vaccination with MicronJet600; Device: BCG vaccination with conventional needle Sponsor: Yonsei University Enrolling by invitation
[AIM] Maputo -The United States government, through the US Agency for International Development (USAID), will provide 20 million dollars to finance the fight against tuberculosis in Mozambique.