What is Legionnaires' disease and how many people does it affect?

Legionnaires' disease is a serious type of pneumonia caused by the Legionella bacterium, which is found in fresh water, according to the US Centers for Disease Control and Prevention.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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The U.S. needs stronger policies and guidance to combat Legionnaires’ disease, a form of pneumonia caused by inhaling air contaminated with Legionella bacteria from water systems, says a new report from the National Academies. Currently there is an absence of regulations that can broadly control the presence of Legionella in water systems. The report calls for a range of actions to combat the growth of the bacteria, such as ensuring that hot water temperatures in buildings are high enough, requiring a minimum level of disinfectant in public water systems, and providing homeowners with more guidance on how to prevent ...
Source: News from the National Academies - Category: Science Source Type: news
AbstractPurpose of ReviewLegionella bacteria cause Legionnaires ’ disease (LD), a severe and potentially fatal pneumonia. Legionellosis has been increasing in the USA and in Europe. We reviewed the literature to describe host factors predisposing to LD, environmental factors facilitatingLegionella proliferation, and transmission modes leading to legionellosis cases and outbreaks.FindingsMen, smokers, and persons 50  years and older, or with chronic pulmonary or immunocompromising conditions, are at risk for LD. Stagnated water and warm water temperature promoteLegionella growth. Most legionellosis cases result f...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
Publication date: Available online 25 July 2019Source: Journal of Molecular BiologyAuthor(s): Xin Liu, Sunny ShinAbstractLegionella pneumophila is the causative agent of the severe pneumonia Legionnaires’ disease. L. pneumophila is ubiquitously found in freshwater environments, where it replicates within free-living protozoa. Aerosolization of contaminated water supplies allows the bacteria to be inhaled into the human lung, where L. pneumophila can be phagocytosed by alveolar macrophages and replicate intracellularly. The Dot/Icm type IV secretion system (T4SS) is one of the key virulence factors required for intrac...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
In this study, a recently introduced immunochromatographic test (Immunocatch Legionella; Eiken Chemical Co., Ltd.) for Legionella pneumophila (serogroup 1) urinary antigen detection was compared with the Sofia Legionella fluorescent immunoassay (FIA) (Quidel) (routinely used in our laboratory) and with the widely used BinaxNOW Legionella assay (Alere). A total of 248 urine samples (60 frozen and 188 fresh) were evaluated. All of the samples were collected from patients with high clinical suspicion of Legionnaires’ disease. The three assays were performed simultaneously according to the manufacturers’ instructio...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Bacteriology Source Type: research
The Sheraton Atlanta has closed for investigation after six guests who stayed there at the same time were diagnosed with Legionnaires' disease, which is a severe form of pneumonia.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Oda N, Hirahara T, Fujioka Y, Mitani R, Takata I Abstract We herein report the case of a 62-year-old man diagnosed with Legionella pneumonia while engaged in recovery work in a flooded area after the Heavy Rain Event of July 2018 in Japan. The patient was intubated and maintained on mechanical ventilation and continuous hemodiafiltration. He was also administered antimicrobial therapy with ciprofloxacin and azithromycin. After 53 days in the hospital, he was discharged. It is important to recognize the risk of Legionella infection and to take measures to prevent it during recovery work that involves exposu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Two patients at Advocate Christ Medical Center in Oak Lawn, Illinois were diagnosed with Legionnaires' disease, a severe from of pneumonia, within the past two months.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 25 June 2019Source: Microbes and InfectionAuthor(s): Laure Gomez-Valero, Carmen BuchrieserAbstractLegionella pneumophila is an intracellular pathogen that causes a severe pneumonia called Legionnaires’ disease that is often fatal when not promptly diagnosed and treated. Legionella parasitize aquatic protozoa with which it co-evolved over an evolutionary long time. The close relationship between hosts and pathogens, their co-evolution, led to molecular interactions such as the exchange of genetic material through horizontal gene transfer (HGT). Genome sequencing of L. pneumophila and...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Abstract The amoeba-resistant bacterium Legionella pneumophila infects humans through aerosols and thereby can cause a life-threatening pneumonia termed Legionnaires' disease. In the environment L. pneumophila forms and colonizes biofilms, which usually comprise complex multispecies communities. In these biofilms L. pneumophila persists and replicates intracellularly in protozoa, such as the amoeba Acanthamoeba castellanii. The interactions between sessile L. pneumophila in biofilms and their natural protozoan hosts are not understood on a molecular level. Here, we describe a method to visualize by confocal m...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Over the past decade, the reported incidence of Legionnaires' disease (LD) in the Northeastern US has increased, reaching 1-3 cases per 100,000. There is reason to suspect this is an underestimate of the true burden as cases may be underdiagnosed. In this analysis of pneumonia and influenza hospitalizations (P&I), we estimate the percentage of cases due to Legionella, influenza and RSV by age group. We fit mixed effects models to estimate attributable percentage using weekly time series data of P&I hospitalizations in Connecticut from 2000 to 2014. Model-fitted values were used to calculate estimates of P...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
More News: Centers for Disease Control and Prevention (CDC) | Health | Legionnaires' Disease | Pneumonia