Gene that 'protects against Alzheimer's' could lead to 'new treatments for the disease'

Scientists at Washington University in St Louis analysed spinal fluid samples from around 800 participants. Some had the memory-robbing disorder.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Normal pressure hydrocephalus, which causes mobility and memory issues, can be mistaken for dementia.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Publication date: Available online 23 August 2019Source: Alzheimer's &DementiaAuthor(s): Carla M. Startin, Sarah Hamburg, Rosalyn Hithersay, Tamara Al-Janabi, Kin Y. Mok, John Hardy, Andre Strydom
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Authors: Ma F, Lv X, Du Y, Chen H, Liu S, Zhao J, Gao Y, An P, Zhou X, Song A, Sun C, Wang G, Ji Y, Wang X, Xu W, Huang G Abstract BACKGROUND: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear. OBJECTIVES: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association. METHODS: This case-...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S Abstract OBJECTIVE: Gut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. BACKGROUND: AD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, whereas the microbiota in MCI before the onset of dementia has not been discovered and characterized in hum...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 22 August 2019Source: NeuroImageAuthor(s): Eunho Lee, Jun-Sik Choi, Minjeong Kim, Heung-Il Suk, the Alzheimer's Disease Neuroimaging InitiativeAbstractIn this paper, we propose a novel method for magnetic resonance imaging based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis that systematically integrates voxel-based, region-based, and patch-based approaches into a unified framework. Specifically, we parcellate the brain into predefined regions based on anatomical knowledge (i.e., templates) and derive complex nonlinear relationships among voxels, whose intensities ...
Source: NeuroImage - Category: Neuroscience Source Type: research
Psychosis is a complex phenotype reflecting a complex biology. Because its comorbid presentation with Alzheimer's Disease (AD) predicts a malignant clinical course, there is an urgency to understand the pathophysiology of, and therapeutic options for, psychosis in AD. Krivinko et al.1 summarize efforts to use animal models to meet this need, and plot a map for future studies.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research
On average, family members spend nearly 22 hours each week caring for parents, grandparents and siblings with Alzheimer's and other conditions. But a new intervention may give them back some of those lost sleep hours.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
We examined two separate cohorts (N = 126; N = 112) of cognitively normal controls, early and late mild cognitive impairment (MCI), and Alzheimer's disease. Demographic, clinical, diffusion-weighted and T1-weighted imaging, and positron emission tomography (PET) imaging were assessed. Results indicated elevated hippocampal free-water in early MCI individuals compared to controls across both cohorts. In contrast, there was no difference in volume of these regions between controls and early MCI. ADNI free-water values in the hippocampus was associated with low CSF AB1–42 levels and high global amyloid PET value...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsThis is the first report about the evaluation of AChE inhibitory activity and phytochemical profiles of D. auriculatum, led to the identification of 36 compounds including alkaloids and flavonoids, and five alkaloids exhibited a significant AChE inhibitory activity and had the potential as AChE inhibitors. This study provided scientific experimental basis for the traditional efficacy of neurological disease of the plant.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Our results suggest that downregulation of kdm4a expression may be a potential therapeutic target in AD. PMID: 31436053 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
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