Association of high amounts of physical activity with mortality risk: a systematic review and meta-analysis.

Association of high amounts of physical activity with mortality risk: a systematic review and meta-analysis. Br J Sports Med. 2019 Aug 12;: Authors: Blond K, Brinkløv CF, Ried-Larsen M, Crippa A, Grøntved A Abstract OBJECTIVES: To systematically review and analyse studies of high amounts of physical activity and mortality risk in the general population. ELIGIBILITY CRITERIA: Inclusion criteria related to follow-up (minimum 2 years), outcome (mortality from all causes, cancer, cardiovascular disease (CVD) or coronary heart disease), exposure (eg, a category of >1000 metabolic equivalent of task (MET) min/week), study design (prospective cohort, nested case control or case-cohort) and reports of cases and person years of exposure categories. INFORMATION SOURCES: Systematic searches were conducted in Embase and Pubmed from database inception to 2 March 2019. RISK OF BIAS: The quality of the studies was assessed with the Newcastle-Ottawa scale. INCLUDED STUDIES: From 31 368 studies identified, 48 were included. Two authors independently extracted outcome estimates and assessed study quality. SYNTHESIS OF RESULTS: We estimated hazard ratios (HRs) using random effect restricted cubic spline dose-response meta-analyses. Compared with the recommended level of physical activity (750 MET min/week), mortality risk was lower at physical activity levels exceeding the recommendations, at least until 5...
Source: British Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Br J Sports Med Source Type: research