Elastic titin properties and protein quality control in the aging heart

This article is part of a Special Issue entitled: Cardiomyocyte biology: new pathways of differentiation and regeneration edited by Marijke Brinkm, Marcus C. Schaub, and Christian Zuppinger.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research

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Condition:   Acute Heart Failure Interventions:   Drug: Standard diuretic therapy;   Drug: Early sequential nephron blockade Sponsors:   University of Parma;   Azienda Ospedaliero-Universitaria di Parma;   Azienda USL di Parma;   Azienda Unità Sanitaria Locale Reggio Emilia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Heart Failure Intervention:   Other: Mortality and Rehospitalization rate Sponsors:   Shanghai 10th People's Hospital;   First Affiliated Hospital, Sun Yat-Sen University;   Nanfang Hospital of Southern Medical University;   Beijing Chao Yang Hospital;   First Hospital of China Medical University;   Yangpu District Central Hospital Affiliated to Tongji U niversity;   Xuhui Central Hospital, Shanghai;   Ningbo Medi...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Heart Failure Interventions:   Other: Multifaceted strategy based on sending text messages(SMS);   Other: Usual outpatient care Sponsors:   Hospital do Coracao;   Hospital Moinhos de Vento Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Heart Failure;   End Stage Renal Disease Intervention:   Diagnostic Test: Diagnostic biomarker study Sponsors:   Hannover Medical School;   Institut National de la Santé Et de la Recherche Médicale, France;   F-CRIN Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractThere are few data on the effects of low hemoglobine levels on the left atrium (LA) in anemic patients. Our aim was to evaluate left atrial (LA) volume and functions in anemic patients using real time three-dimensional echocardiography (RT3DE) and also to investigate changes in variables of LA after the correction of anemia. In total, 55 iron-deficiency anemia patients without traditional cardiovascular (CV) risk factors and 30 age- and gender-matched controls were studied. Assessments included history, physical examination and echocardiography. Of the 55 patients with anemia enrolled, 50 (39 females and 11 males 4...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractPulmonary arterial hypertension (PAH) is a serious and often fatal complication of connective tissue disease (CTD). Right atrial (RA) function is essential to maintaining adequate total right heart function in PAH. However, little is known about prognostic utility of RA function in CTD-PAH. RA longitudinal strain (LS) and strain rate (LSR) were evaluated in 53 consecutive patients (51 female, mean age 42  ± 15 years) with CTD-PAH, including systemic lupus erythematosus (SLE) (33.7%), mixed connective tissue disease (MCTD) (32.1%), primary Sjögren’s syndrome (pSS) (26.4%), and sy...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
ntilde;as R Abstract The pentapeptides methionine-enkephalin and leucine-enkephalin belong to the opioid family of peptides, and the non-opiate peptide adrenocorticotropin hormone (ACTH) to the melanocortin peptide family. Enkephalins/ACTH are derived from pro-enkephalin, pro-dynorphin or pro-opiomelanocortin precursors and, via opioid and melanocortin receptors, are responsible for many biological activities. Enkephalins exhibit the highest affinity for the δ receptor, followed by the μ and κ receptors, whereas ACTH binds to the five subtypes of melanocortin receptor, and is the only member of the ...
Source: Vitamins and Hormones - Category: Endocrinology Authors: Tags: Vitam Horm Source Type: research
AstraZeneca made strides on Tuesday toward its goal of adding heart failure to the conditions that can be treated by its diabetes drug Farxiga, putting it ahead of a rival medicine from Eli Lilly.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
ConclusionsFibroblast growth factor 21 (FGF ‐21) levels were elevated in patients with HFrEF and cardiac cachexia, which could be mediated by increased inflammation and muscle wasting rather than impaired cardiac function.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
AbstractBackgroundThe complexity of diagnosis for critically ill dyspnea presentations in the emergency department remains a challenge. Accurate and rapid recognition of associated life-threatening conditions is paramount for timely treatment. Point-of-care ultrasound (POCUS) has been shown to impact the diagnosis of dyspnea presentations in resource-rich settings, and may be of greater diagnostic benefit in resource-limited settings.MethodsWe prospectively enrolled a convenience sample of 100 patients presenting with dyspnea in the Emergency Department at University Teaching Hospital of Kigali (UTH-K) in Rwanda. After a t...
Source: Critical Ultrasound Journal - Category: Radiology Source Type: research
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