The Surge of Fentanyl and Other Synthetic Opioids

How is the illicit flow of fentanyl and other synthetic opioids impacting communities across the United States? A recent RAND report examined mortality and seizure data at the state level across several drug classes to better understand the evolution and concentration of overdose fatalities in the United States.
Source: RAND Research Health and Health Care - Category: Health Management Authors: Source Type: research

Related Links:

The Hawaii Department of Health received an additional $4 million in federal grant funds toward opioid prevention in Hawaii earlier this week. To date, the U.S. Department of Health and Human Services has released a total of $1.8 billion across the nation with hopes of expanding access to opioid misuse treatment and supporting data on drug overdoses. “Hawaii’s initiative aligns with HHS’s five-point strategy for combating the national opioid crisis,” said Ed Heidig, regional director of…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Publication date: Available online 17 September 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Ireneusz P. Grudzinski, Monika Ruzycka, Andrzej Cieszanowski, Wojciech Szeszkowski, Iwona Badurek, Anna Malkowska, Magdalena Bamburowicz-KlimkowskaAbstractWorldwide, drug-induced liver injury (DILI) is a major cause of hepatic failure. It is also the leading cause of withdrawal, cautionary labeling, and restricted usage of licensed drugs; therefore, European Medicines Agency (EMA) and United States Food and Drug Administration (FDA) warn that the existing methods of assessing DILI are insufficient and that some of t...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
WEDNESDAY, Sept. 18, 2019 -- Addiction and overdose deaths aren't the only consequence of America's opioid epidemic. Cases of a potentially deadly heart infection have risen alarmingly, too, a new study finds. This bacterial infection, called...
Source: - Daily MedNews - Category: General Medicine Source Type: news
Pennsylvania opioid-overdose admissions dropped by 833 in 2018, a nearly 24% decrease when compared to the previous year, according to a report released Wednesday by the Pennsylvania Health Care Cost Containment Council. PHC4 research shows that the number of overdose admissions at Pennsylvania hospitals was 3,342 in 2016, 3,500 in 2017 and 2,667 last year. Joe Martin, PHC4 executive director, said the findings support other opioid-related data for Pennsylvania, including a decrease in overdose…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and neuropsychological effects of opioid use disorder (OUD). Polymorphisms disrupting the opioid and dopamine systems have been associated with increased risk for developing substance use disorders. Molecular imaging studies have revealed how these polymorphisms impact the brain and contribute to cognitive and behavioral differences across individuals. Here, we review the curr...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we examined whether pharmacological inhibition of Cystlr1 could protect mice against APAP-induced hepatic damage. We found that APAP treatment upregulated messenger RNA and protein levels of Cysltr1 both in vitro and in vivo. Pharmacological inhibition of Cysltr1 by montelukast ameliorated APAP-induced acute liver failure. The hepatoprotective effect of montelukast was associated with upregulation of hepatic glutathione/glutathione disulfide level, reduction in c-Jun-NH2-terminal kinase activation and oxidative stress. In mouse primary hepatocytes, inhibition of Cysltr1 by montelukast ameliorated the express...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractGlobally, chronic pain is a major therapeutic challenge and affects more than 15% of the population. As patients with painful terminal diseases may face unbearable pain, there is a need for more potent analgesics. Although opioid-based therapeutic agents received attention to manage severe pain, their adverse drug effects and mortality rate associated with opioids overdose are the major concerns. Evidences from clinical trials showed therapeutic benefits of cannabis, especially delta-9-tetrahydrocannabinol and cannabinoids reduced neuropathic pain intensity in various conditions. Also, there are reports on using co...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Back in May, Bruce Schoneboom wrapped up his appointment to the HHS Pain Management Best Practices Inter-Agency Task Force. The group determined best practices for managing chronic and acute pain—and addressed judicious prescribing of opioids. If you didn’t know: The CDC reports there are 192 overdose deaths in the U.S. every day. Forty percent of The post Dr. Bruce Schoneboom and the HHS Pain Task Force appeared first on Johns Hopkins Nursing Magazine.
Source: Nursing Blogs at Johns Hopkins University - Category: Nursing Authors: Tags: New On the Pulse DNP nurse anesthesiology nurse anesthetist pain month Source Type: blogs
Conditions:   Drug Overdose;   Virtual Reality Interventions:   Other: Virtual Reality Education;   Other: Standard Education Sponsor:   University of Pennsylvania Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
The British Columbia government says any proposed settlement from opioid manufacturer Purdue Pharma needs to include Canadian claims for the devastation created by the overdose crisis.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
More News: Fentanyl | Health Management | Overdose | USA Health