Genes, Vol. 10, Pages 618: Host Invasion by Pathogenic Amoebae: Epithelial Disruption by Parasite Proteins

Genes, Vol. 10, Pages 618: Host Invasion by Pathogenic Amoebae: Epithelial Disruption by Parasite Proteins Genes doi: 10.3390/genes10080618 Authors: Betanzos Bañuelos Orozco The epithelium represents the first and most extensive line of defence against pathogens, toxins and pollutant agents in humans. In general, pathogens have developed strategies to overcome this barrier and use it as an entrance to the organism. Entamoeba histolytica, Naegleria fowleri and Acanthamoeba spp. are amoebae mainly responsible for intestinal dysentery, meningoencephalitis and keratitis, respectively. These amoebae cause significant morbidity and mortality rates. Thus, the identification, characterization and validation of molecules participating in host-parasite interactions can provide attractive targets to timely intervene disease progress. In this work, we present a compendium of the parasite adhesins, lectins, proteases, hydrolases, kinases, and others, that participate in key pathogenic events. Special focus is made for the analysis of assorted molecules and mechanisms involved in the interaction of the parasites with epithelial surface receptors, changes in epithelial junctional markers, implications on the barrier function, among others. This review allows the assessment of initial host-pathogen interaction, to correlate it to the potential of parasite invasion.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research

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Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
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Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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Source: EurekAlert! - Biology - Category: Biology Source Type: news
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Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Biology Microbiology Medical research Israel Archaeology Middle East and North Africa World news Source Type: news
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Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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Source: EurekAlert! - Biology - Category: Biology Source Type: news
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Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
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Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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