The antibiotics of the future might come from... fish slime?

(Natural News) The mucus layer of fish protect them from injuries and harmful infections. Certain beneficial bacteria that live in fish slime might help in the development of new antimicrobial treatments for drug-resistant infections. Excessive use of antibiotics for treating minor diseases and for fattening animals has led to the appearance of multidrug-resistant bacteria. This has caused...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Publication date: 15 January 2020Source: Chemical Engineering Journal, Volume 380Author(s): Xiaojuan Zhang, Chuanchuan He, Ruicong Yan, Yan Chen, Pengxuan Zhao, Minsi Li, Ting Fan, Tan Yang, Yao Lu, Jun Luo, Xiang Ma, Guangya XiangAbstractThe clinical efficacy of cisplatin (DDP) treatment is largely limited by cisplatin resistance, which is related to the activation of hypoxia-inducible factor 1 (HIF-1). The HIF-1 activation can be induced by low oxygen availability as well as chemotherapeutics in a reactive oxygen species (ROS) dependent manner. Here, instead of the traditional ROS elevation strategy, we designed a chitos...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
In this report, a new method for rapid and sensitive detection of Mrp2 function was established via using mouse small intestinal organoids. Firstly, small intestinal crypts isolated from mouse intestine were induced by Noggin, R-spondin1 and EGF to develop three-dimensional (3D) organoids. Secondly, the 3D organoids were characterized by the physical and physiological structure of Mrp2-mediated drug transport. Finally, Mrp2 fluorescent substrate 5(6)-carboxyl- 2′, 7′-dichlorofluorescein (CDF) and its inhibitor MK-571 and probenecid were used to demonstrate Mrp2-mediated CDF transport in 3D organoids. The result...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
CONCLUSIONS: There is a clear correlation between ARM56/58 upregulation and Sb resistance in AT-harbouring patients, suggesting the use of these markers as potential indicators to help the treatment choice and outcome, preventing therapeutic failure. PMID: 31433006 [PubMed - in process]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
ConclusionTo our knowledge, this is the first draft genome of Chinese giant salamander original M. morganii strain harboring multiple antibiotic resistance genes in China. The reported genome sequence could provide insights about antibiotic resistance mechanisms and control strategies of M. morganii.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionThis is the first report of the genome sequence of A. baumannii ST1928 clinical isolate carrying a novel class C β-lactamase gene from China. The genome sequence data can be used as a reference sequence for comparative studies and would facilitate further understanding of the antibiotic resistance mechanisms of A. baumannii at the genomic level.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionThe genome sequence data presented in this study can serve as an important reference sequence for further understanding of the antimicrobial resistance mechanisms and virulence potientials of this bacterial species.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionThe results of this study reveal thatEnterobacter spp. isolates from hospital settings are both resistant to clinically-used antibiotics and tolerant to biocides. Biocide tolerance could be an advantage for antibiotic-resistant strains in hospitals.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLES Source Type: research
Source: International Journal of Tuberculosis and Lung Disease - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLES Source Type: research
ABSTRACT: Introduction: The mortality rate among tuberculosis patients (TB fatality) has been attributed to irregular chemotherapy, delay in diagnosis, multidrug resistance, and HIV coinfection. Objective: To analyze TB fatality rates by sex, clinical presentation and HIV coinfection in Campinas, S ão Paulo, Brazil. Methods: Cohorts of residents in the city of Campinas who either died during treatment for tuberculosis or had the disease confirmed after death were divided into three intervals: 2001-2003, 2004-2006, and 2007-2009. Data were obtained from the database of the Tuberculosis Surve illance System of the Uni...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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