Characterization of activating mutations of the < i > MEK1 < /i > gene in papillary thyroid carcinomas.

CONCLUSIONS: In this study, we report the occurrence of functional <i>MEK1 </i>mutations in papillary thyroid cancer. All mutations are in-frame deletion in exon 3 of <i>MEK1</i>, representing another mechanism of activation of the MAPK pathway in papillary carcinomas with predominantly follicular growth pattern. PMID: 31407636 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research