Mortality risk of nonoperative papillary thyroid carcinoma: a corollary for active surveillance.

Mortality risk of nonoperative papillary thyroid carcinoma: a corollary for active surveillance. Thyroid. 2019 Aug 13;: Authors: Ho AS, Luu M, Zalt C, Morris LGT, Chen I, Melany M, Ali N, Patio C, Chen Y, Mallen-St Clair J, Braunstein G, Sacks W, Zumsteg ZS Abstract Background Active surveillance is established as an alternative to surgery for papillary thyroid microcarcinomas, but inclusion criteria and mortality risk for pursuing a nonsurgical approach have not been clearly defined. To gauge the feasibility of expanding active surveillance thresholds, we investigated the effects of increasing size and age on disease-specific survival in a large nonoperative thyroid cancer cohort, compared against a matched group of surgical patients. Methods Papillary thyroid carcinoma patients staged T1-4N0M0 were identified in the Surveillance, Epidemiology, and End Results (SEER) database between 1975-2015, stratified by nonsurgical and surgical management. Propensity score matching was performed to adjust for imbalances in covariates. Multivariable models were constructed using restricted cubic splines to model non-linear relationships of age and tumor size with disease-specific survival (DSS). Results Overall, 1,453 nonoperative patients and 54,718 surgical patients met inclusion criteria. Collectively, increasing age and size after certain thresholds independently led to greater differences in DSS between nonsurgical and surgical patients. For younger ages (14-55 ...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research

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Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSION: Expression of a constitutively activated ALK mutant in thyroids of mice leads to development of metastasizing thyroid cancer resembling human PDTC. These results demonstrate in vivo that increased ALK activity is a driver mechanism in thyroid carcinogenesis. PMID: 31526103 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
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Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
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Source: Endocrine Pathology - Category: Pathology Source Type: research
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