Late Peaks of HMGB1 and Sepsis Outcome: Evidence For Synergy With Chronic Inflammatory Disorders

This study aimed to assess the impact of HMGB1 kinetics on 28-day mortality. In a sub-study of a previous randomized clinical trial among patients with systemic inflammatory response syndrome and gram-negative infections, patients were classified in early and late HMGB1 peak groups. Serial measurements of HMGB1, ferritin and interferon-gamma (IFNγ) were performed in all available sera. Two hundred ten patients were included; 118 (46.5%) had at least one inflammatory disease (diabetes, chronic obstructive pulmonary disease, chronic heart failure, or chronic renal disease). Mortality after 28 days was higher among patients with a late peak of HMGB1 (OR 2.640; P = 0.026). Co-existence of late peak and inflammatory disease synergistically impacted mortality (odds ratio of logistic regression analysis 3.17; P: 0.027). Late peak was concomitantly associated with higher values of ferritin (P = 0.035), and IFNγ (P = 0.002) among patients with hyperferritinemia. It is concluded that late HMGB1 peak was associated with worse prognosis, especially in patients with underlying chronic inflammatory conditions.
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
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Source: International Journal of Integrated Care - Category: Nursing Source Type: research
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Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
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Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Healthcare Delivery Healthcare Information Technology Healthcare Innovations Point-of-Care Testing Public Health Telemedicine Source Type: blogs
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Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
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Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
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Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
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Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Pharm Des Source Type: research
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