The mechanism of RNA oxidation involved in the development of heart failure.

The mechanism of RNA oxidation involved in the development of heart failure. Free Radic Res. 2019 Aug 12;:1-12 Authors: Liu T, Cai JP, Zhang LQ, Sun N, Cui J, Wang H, Yang JF Abstract Heart failure (HF) has become a global public health problem due to its unclear pathogenesis. Our previous studies have found that RNA oxidation is associated with the occurrence and development of a variety of chronic diseases in the elderly, but whether RNA oxidation is related to the pathogenesis of HF remains unclear. Male Dahl salt-sensitive rats (DSSR) were divided into 8% NaCl groups and 0.3% NaCl groups. The blood pressure of DSSR, HE staining of cardiac tissue, cardiac function index of colour Doppler echocardiography and plasma N-terminal probrain Natriuretic Peptide (NT-ProBNP) were used to evaluate the model making. The levels of 8-hydroxyguanosine (8-oxoGsn) and 8-hydroxydeoxyguanosine (8-oxodGsn) in myocardium and urine of DSSR were determined by high-performance liquid chromatography-mass spectrometry (LC-MS/MS). The expression of ERK-MAPK pathway and MTH1 was detected by Western blot (WB). Rats in the 8% NaCl group developed heart failure symptoms such as increased blood pressure, myocardial hypertrophy, decreased diastolic function, and increased plasma NT-ProBNP. The content of 8-oxoGsn in urine and heart tissue also increased, which was positively correlated with the related indicators of heart failure. This process is also accompanied by the sequential ac...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research

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Condition:   Acute Heart Failure Interventions:   Drug: Standard diuretic therapy;   Drug: Early sequential nephron blockade Sponsors:   University of Parma;   Azienda Ospedaliero-Universitaria di Parma;   Azienda USL di Parma;   Azienda Unità Sanitaria Locale Reggio Emilia Not yet recruiting
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Condition:   Heart Failure Intervention:   Other: Mortality and Rehospitalization rate Sponsors:   Shanghai 10th People's Hospital;   First Affiliated Hospital, Sun Yat-Sen University;   Nanfang Hospital of Southern Medical University;   Beijing Chao Yang Hospital;   First Hospital of China Medical University;   Yangpu District Central Hospital Affiliated to Tongji U niversity;   Xuhui Central Hospital, Shanghai;   Ningbo Medi...
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Condition:   Heart Failure Interventions:   Other: Multifaceted strategy based on sending text messages(SMS);   Other: Usual outpatient care Sponsors:   Hospital do Coracao;   Hospital Moinhos de Vento Recruiting
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Conditions:   Heart Failure;   End Stage Renal Disease Intervention:   Diagnostic Test: Diagnostic biomarker study Sponsors:   Hannover Medical School;   Institut National de la Santé Et de la Recherche Médicale, France;   F-CRIN Completed
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AbstractThere are few data on the effects of low hemoglobine levels on the left atrium (LA) in anemic patients. Our aim was to evaluate left atrial (LA) volume and functions in anemic patients using real time three-dimensional echocardiography (RT3DE) and also to investigate changes in variables of LA after the correction of anemia. In total, 55 iron-deficiency anemia patients without traditional cardiovascular (CV) risk factors and 30 age- and gender-matched controls were studied. Assessments included history, physical examination and echocardiography. Of the 55 patients with anemia enrolled, 50 (39 females and 11 males 4...
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AbstractPulmonary arterial hypertension (PAH) is a serious and often fatal complication of connective tissue disease (CTD). Right atrial (RA) function is essential to maintaining adequate total right heart function in PAH. However, little is known about prognostic utility of RA function in CTD-PAH. RA longitudinal strain (LS) and strain rate (LSR) were evaluated in 53 consecutive patients (51 female, mean age 42  ± 15 years) with CTD-PAH, including systemic lupus erythematosus (SLE) (33.7%), mixed connective tissue disease (MCTD) (32.1%), primary Sjögren’s syndrome (pSS) (26.4%), and sy...
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ntilde;as R Abstract The pentapeptides methionine-enkephalin and leucine-enkephalin belong to the opioid family of peptides, and the non-opiate peptide adrenocorticotropin hormone (ACTH) to the melanocortin peptide family. Enkephalins/ACTH are derived from pro-enkephalin, pro-dynorphin or pro-opiomelanocortin precursors and, via opioid and melanocortin receptors, are responsible for many biological activities. Enkephalins exhibit the highest affinity for the δ receptor, followed by the μ and κ receptors, whereas ACTH binds to the five subtypes of melanocortin receptor, and is the only member of the ...
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AstraZeneca made strides on Tuesday toward its goal of adding heart failure to the conditions that can be treated by its diabetes drug Farxiga, putting it ahead of a rival medicine from Eli Lilly.
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ConclusionsFibroblast growth factor 21 (FGF ‐21) levels were elevated in patients with HFrEF and cardiac cachexia, which could be mediated by increased inflammation and muscle wasting rather than impaired cardiac function.
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