Iris melanoma associated with unilateral phthisis bulbi in a 13-year-old Domestic Shorthair female cat.

Iris melanoma associated with unilateral phthisis bulbi in a 13-year-old Domestic Shorthair female cat. Vet Q. 2019 Aug 10;:1-8 Authors: Lamagna B, Uccello V, Prisco F, Russo V, Lamagna F, Navas L, Mennonna G, Murino C, Meomartino L Abstract A 13-year-old Domestic Shorthair female cat, with a history of phthisis bulbi of the right eye, was referred for an acute increase in the size of the right ocular globe that occurred over a period of 1 month. Ocular examination revealed a large pink/greyish neoplastic mass involving the entire ocular surface. Ocular ultrasound and cytological examination confirmed intraocular tumor of the phthisical eye extending into the cranial space of the right orbit. The diagnosis of a primary, poorly pigmented iris melanoma was confirmed by histology and immunohistochemistry after exenteration. Fourteen months after surgery, the cat died, and complete necropsy was performed. Histological examination of the autopsy samples showed metastases to regional lymph nodes, lung, liver, and kidneys. This is the first reported case of an iris melanoma associated with phthisis bulbi in a cat. Early enucleation or monitoring of hypotonic blind eyes in cats is recommended. PMID: 31401942 [PubMed - as supplied by publisher]
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research

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Mrittika Sen, Santosh G HonavarIndian Journal of Ophthalmology 2019 67(12):1965-1973 Circumscribed choroidal hemangioma is a benign vascular tumor which presents in middle-aged adults with progressive diminution of vision, metamorphopsia, floaters, and visual field defects. Diagnosis is based on the characteristic clinical features. It is an orange-red, usually solitary, tumor situated in the posterior pole. The visual symptoms are because of the associated subretinal fluid, cystoid macular edema, and, in long-standing cases, retinal pigment epithelium changes, subretinal fibrosis and retinoschisis. It must be distinguish...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Uveal melanoma (UM), the most common primary intraocular tumour, is often complicated by exudative retinal detachment (RD). Sometimes, this exudative RD is mistaken for a rhegmatogenous detachment and is subsequently treated with vitrectomy with silicone oil (SiOil) tamponade. As SiOil prevents ultrasound imaging, the diagnosis, treatment planning and/or follow-up of UM underlying the detachment are often severely hindered by the SiOil. We aim to develop and evaluate new MRI methods to image UM patients with a SiOil tamponade and evaluate this in vivo. A dedicated MRI protocol for 3 and 7 T was developed and subsequently e...
Source: Melanoma Research - Category: Cancer & Oncology Tags: Short Communications Source Type: research
Authors: Coroi MC, Bakraoui A, Sala C, Ţica O, Ţica OA, Jurcă MC, Jurcă AD, Holhoş LB, Bălăşoiu AT, Todor L Abstract Uveal melanoma is the most common intraocular tumor characterized by increased metastatic potential. The tumor develops from uveal melanocytes that, from an embryological point of view, derive from the cells of the anterior neural crest. The risk factors associated with melanoma development are close related to patient phenotype: light-colored hair and iris, fair skin. Recent studies have shown the link between choroidal melanoma and choroidal pigmentation of white-haired and light-colored ey...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Purpose: To identify the most accurate ultrasonographic technique to measure the largest basal dimension (LBD) of choroidal melanoma. Methods: B-scan ultrasound images were retrospectively reviewed in 99 eyes of 99 choroidal melanoma patients. The LBD was measured using one, two, and three straight lines along the inner and outer sclera. Theoretical arc length, calculated using trigonometry formulas based on the spherical model with the axial length as the sphere diameter, was used for comparisons with the actual measurements using straight lines. Results: For straight-line measurements in the inner sclera, the low...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
CONCLUSION: The ultra-wide-field scanning laser ophthalmoscopy imaging characteristics of choroidal melanoma in the Optos® system do not significantly change after proton beam radiotherapy after a mean follow-up of 2 years. PMID: 31466473 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
le Parrozzani Intraocular tumor diagnosis is based on clinical findings supported by additional imaging tools, such as ultrasound, optical coherence tomography and angiographic techniques, usually without the need for invasive procedures or tissue sampling. Despite improvements in the local treatment of uveal melanoma (UM), the prevention and treatment of the metastatic disease remain unsolved, and nearly 50% of patients develop liver metastasis. The current model suggests that tumor cells have already spread by the time of diagnosis, remaining dormant until there are favorable conditions. Tumor sampling procedures at ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion: Swept-source optical coherence tomography angiography represents a valid imaging technique to evaluate patients affected by choroidal melanomas. In our series, SS-OCT-A disclosed the intrinsic microvasculature of the tumor in all cases despite their size, location, and history of previous treatments.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
CONCLUSION: Optical coherence tomography angiography can provide useful information for assessing and differentiating between choroidal nevi and small melanomas. Significant differences between these conditions were found for the pattern of reflectivity, and presence/absence of avascular zones and vascular anomalies, which could be helpful for supporting the diagnosis. PMID: 31210061 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION:: This case shows that metastatic choroidal melanoma can present in the same eye as the primary tumor. It also shows that systemic immunotherapy can control both ocular and systemic metastases as well as prolong both life and sight. PMID: 30943789 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
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