Severe tracheal stenosis after first administration of pembrolizumab rescued by Dumon Y-stent in a lung cancer patient

Publication date: Available online 12 August 2019Source: Respiratory Medicine Case ReportsAuthor(s): Daisuke Himeji, Gen-ichi Tanaka, Chikara Fukuyama, Atsushi Yamanaka, Ritsuya Shiiba, Sayaka Moriguchi, Kousuke MarutsukaAbstractA 70-year-old woman diagnosed with advanced, non-resectable programmed cell death ligand 1-positive-non-small-cell lung carcinoma was treated with pembrolizumab as first-line therapy. Soon after therapy initiation, she presented with severe dyspnea, and chest computed tomography revealed a soft tissue mass in the lower trachea of the right main bronchus. During bronchoscopy, she became severely hypoxic, and we performed endoscopic tumor ablation and Dumon Y-stent placement. We considered this severe deterioration caused by pseudoprogression, and suggest that it is necessary to perform bronchoscopy and to prepare for the bronchial intervention when treating patients with immune checkpoint inhibitors.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research

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Conclusion: Our data provide evidence that homing of breast cancer cells is independent of their ER status and that the breast cancer bone metastasis niche is located within the trabecular region of bone, an area rich in osteoblasts and microvessels. The increased number of breast cancer cells homing to bone after mobilisation of HSCs suggests that the HSC and the bone metastasis niche overlap.
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Date: Thursday, 10 31, 2019; Speaker: Angelika Amon, Ph.D., Professor of Biology , Massachusetts Institute of Technology; Building: Building 50; Room 1227/1233
Source: NIH Calendar of Events - Category: American Health Source Type: events
Conclusions: The predictability of the Blue Cross models show how member-specific, regional data can be used to accurately identify patients with a high ROH, which may allow healthcare workers to intervene earlier and subsequently reduce the healthcare burden for patients and providers. PMID: 31505982 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Conclusions The swab home collection samples were equivalent to the clinical samples, but the tampon method had an unacceptably high rate of specimens insufficient for HPV detection.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
Authors: Marra G, Dell'oglio P, Baghdadi M, Cathelineau X, Sanchez-Salas R, EvaluatioN of HIFU Hemiablation and short term AndrogeN deprivation therapy Combination to Enhance prostate cancer control (ENHANCE) study investigators Abstract FT for localized PCa is emerging to reduce adverse effects of radical treatments, while maintaining comparable oncological outcomes. However, an area for improvement still exists and a gap in cancer control needs to be filled by complementing the with additional forms of treatment to minimize failures. Part of the recurrences/persistences after FT may be related to PCa microenviron...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
In this study, a series of anthropomorphic software breast phantoms (ASBPs) with various volumes and glandularities were built. The realism of the ASBPs was assessed by using the two-dimensional projection and fractal dimension (FD) analysis. Breast self S values and suborgan S values for 18F and 99mTc were simulated using the Monte Carlo technique. The projected images of the ASBPs were similar to clinical mammograms in tissue distribution and image contrast. The mean FD value for the ASBPs was 2.23. The maximum differences between the breast self S values of ASBPs and OLINDA/EXM for 18F and 99mTc were −14.4% and &m...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Contributors : P Sharma ; W E Barlow ; A K Godwin ; E E Parkes ; L A Knight ; S M Walker ; R D Kennedy ; D P Harkin ; G E Logan ; C J Steele ; S M Lambe ; S Badve ; Y Gokmen-Polar ; H B Pathak ; K Isakova ; H M Linden ; P Porter ; L Pusztai ; A M Thompson ; D Tripathy ; G N Hortobagyi ; D F HayesSeries Type : Expression profiling by arrayOrganism : Homo sapiensPurpose: The purpose of this study was to independently validate two biomarkers, a 44-gene DNA Damage Immune Response (DDIR) signature and stromal tumor-infiltrating lymphocytes (sTILs), as prognostic markers in TNBC patients treated with adjuvant doxorubicin (A) and...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Purnima Gupta ; Naveed Shahzad ; Alexis Robitaille ; Hector Hernandez-Vargas ; Geoffroy Durand ; Florence Le Calvez-Kelm ; Tarik Gheit ; Rosita Accardi ; Massimo TommasinoSeries Type : Expression profiling by arrayOrganism : Homo sapiensMerkel cell polyomavirus (MCPyV) is the first human polyomavirus etiologically associated with Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. Similar to other polyomaviruses, MCPyV encodes early T antigen genes, a viral oncogene required for MCC tumor growth. To identify the unique oncogenic properties of MCPyV, we analysed the gene expression profile...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
We reported the gene expression profiles of 9 human colon cancer samples and their matching adjacent normal tissues.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Mark E. Gray1,2*, James Meehan2,3, Paul Sullivan4, Jamie R. K. Marland4, Stephen N. Greenhalgh1, Rachael Gregson1, Richard Eddie Clutton1, Carol Ward2, Chris Cousens5, David J. Griffiths5, Alan Murray4 and David Argyle1 1The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom 2Cancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3School of Engineering and Physical Sciences, Institute of Sensors, Signals and Systems, Heriot-Watt Univer...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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