The son giving the gift of his voice to his father

Bob Alderman, 70, lost his voice to motor neurone disease - until his son stepped in to help.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Tandem spinal stenosis (TSS) is a rare presentation leading to combined clinical features of upper motor neuron and lower motor neuron lesion which includes intermittent neurogenic claudication with or without neurological deficit, progressive gait imbalance and gait disturbances. Such presentation was usually treated with staged surgery in past and few studies have reported single stage surgical intervention.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
CONCLUSIONS These findings reveal MNX1 as a novel oncogene of cervical cancer and indicate MNX1 is a promising therapeutic and prognostic biomarker. PMID: 31436258 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 21 August 2019Source: Redox BiologyAuthor(s): Bumsoo Ahn, Nataliya Smith, Debra Saunders, Rojina Ranjit, Parker Kneis, Rheal A. Towner, Holly Van RemmenAbstractMitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1−/−) exhibit high levels of oxygen-derived radicals and oxidative damage, associated with neuronal and muscular phenotypes consistent with sarcopenia. We used magnetic resonance...
Source: Redox Biology - Category: Biology Source Type: research
Molecules, Vol. 24, Pages 3043: An Improved HILIC HPLC-MS/MS Method for the Determination of β-ODAP and Its α Isomer in Lathyrus sativus Molecules doi: 10.3390/molecules24173043 Authors: Andreia Bento-Silva Letice Gonçalves Elsa Mecha Filipe Pereira Maria Carlota Vaz Patto Maria do Rosário Bronze β-N-Oxalyl-l-α,β-diaminopropionic acid (β-ODAP) is a non-protein amino acid present in Lathyrus sativus (grass pea) and other Lathyrus species, in parallel with its nontoxic isomer, α-ODAP. When consuming grass pea for several months as stapl...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Crick Institute links up with drug company Merck to tackle degenerative brain disorder
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
ConclusionsThis workshop raised staff awareness on communicating QoL in MND. Future work needs to look into implementing this training in clinical practice and evaluate their impact on QoL in MND.
Source: Quality of Life Research - Category: Health Management Source Type: research
DiscussionOur findings demonstrate atrophy of the upper cervical spinal cord in the motor neuron disease spectrum, which was progressive over time for all but PLS patients. Cervical spinal cord imaging in ALS seems to capture different disease effects than brain neuroimaging. Atrophy of the cervical spinal cord is therefore a promising additional biomarker for both diagnosis and disease progression and could help in the monitoring of treatment effects in future clinical trials.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Myofibrillar myopathies (MFMs) are a genetically heterogeneous group of muscle disorders. Mutations in the filamin C gene (FLNC) have previously been identified in patients with MFM. The phenotypes of FLNC-relate...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
Better care for Parkinson ’s, MS and motor neurone disease Related items fromOnMedica 'Revived' dead pig brains offer new research hopes NICE issues guidelines on neurological conditions GPs have duty to protect abused vulnerable adults NICE sets care standards for spasticity GPs must greatly improve deaf awareness
Source: OnMedica Latest News - Category: UK Health Source Type: news
Abstract Antisense oligonucleotides (ASOs) are a widely used form of gene therapy, which is translatable to multiple disorders. A major obstacle for ASO efficacy is its bioavailability for in vivo and in vitro studies. To overcome this challenge we use cell-penetrating peptides (CPPs) for systemic delivery of ASOs. One of the most advanced clinical uses of ASOs is for the treatment of spinal muscular atrophy (SMA). In this chapter, we describe the techniques used for in vitro screening and analysing in vivo biodistribution of CPP-conjugated ASOs targeting the survival motor neuron 2, SMN2, the dose-dependent modif...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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