Strategies to Adjust Positive End-Expiratory Pressure in Patients With ARDS

To the Editor Dr Beitler and colleagues for the EPVent-2 Study Group conducted a randomized clinical trial of titrating positive end-expiratory pressure (PEEP) according to end-expiratory pleural pressure estimated from esophageal pressure (PES) in patients with acute respiratory distress syndrome (ARDS). The PES approach studied was compelling as a means of individualizing PEEP according to chest wall mechanics. While the results are disappointing, we argue that they are not altogether surprising.
Source: JAMA - Category: General Medicine Source Type: research