Exogenous acquisition of Pseudomonas aeruginosa in intensive care units: a prospective multicentre study, DYNAPYO study.

Publication date: Available online 13 August 2019Source: Journal of Hospital InfectionAuthor(s): Maïder Coppry, Camille Leroyer, Marion Saly, Anne-Gaëlle Venier, Céline Slekovec, Xavier Bertrand, Sylvie Parer, Serge Alfandari, Emmanuelle Cambau, Bruno Megarbane, Christine Lawrence, Bernard Clair, Alain Lepape, Pierre Cassier, Dominique Trivier, Alexandre Boyer, Hélène Boulestreau, Julien Asselineau, Véronique Dubois, Rodolphe ThiébautSummaryPseudomonas aeruginosa remains one of the most common nosocomial pathogens in intensive care units (ICUs). Although exogenous acquisition has been widely documented in outbreaks, its importance is unclear in non-epidemic situations. We aimed to elucidate the role of exogenous origin of P. aeruginosa in ICU patients.We performed a chronological analysis of the acquisition of P. aeruginosa using samples collected in 2009 in DYNAPYO cohort study during which patients and tap water were weekly screened. Molecular relatedness of P. aeruginosa isolates was investigated by pulsed-field gel electrophoresis. Exogenous acquisition was defined as identification of a P. aeruginosa pulsotype previously isolated from another patient or tap water in the ICU.DYNAPYO cohort included 1,808 patients (10,402 samples) and 233 water taps (4,946 samples). Typing of 1,515 isolates from 373 patients and 375 isolates from 81 tap water samples identified 296 pulsotypes. Analysis showed an exogenous acquisition in 170 (45....
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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ConclusionsOur results reaffirm the high clinical and epidemiological impact of the epidemic outbreak in Cantabria and emphasises the need for optimising the current prevention measures against hepatitis A.ResumenAntecedentes y objetivos: Desde junio de 2016 se han producido brotes de hepatitis A en diversos países europeos, afectando principalmente a hombres que tienen sexo con hombres (HSH). El objetivo del presente trabajo fue valorar su impacto clínico y epidemiológico en Cantabria.Materiales y métodosSe recogieron retrospectivamente todos los casos de hepatitis A diagnosticados en Cantabria...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Publication date: Available online 10 November 2019Source: EpidemicsAuthor(s): Lee Worden, Sarah F. Ackley, Jennifer Zipprich, Kathleen Harriman, Wayne T.A. Enanoria, Rae Wannier, Travis C. PorcoAbstractA large measles outbreak in 2014–2015, linked to Disneyland theme parks, attracted international attention, and led to changes in California vaccine policy. We use dates of symptom onset and known epidemic links for California cases in this outbreak to estimate time-varying transmission in the outbreak, and to estimate generation membership of cases probabilistically. We find that transmission declined significantly d...
Source: Epidemics - Category: Epidemiology Source Type: research
[WHO] Abuja -In the short time it has existed, Nigeria's public health institute, the Nigeria Centre for Disease Control (NCDC), has reported, averted and controlled a myriad of disease outbreaks. A key factor in preventing either the occurrence or the spread of these outbreaks has been their early detection.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
An eight-month-old boy is examined by a doctor in Dar es Salaam, Tanzania. Credit: Kristin Palitza/IPS By Ifeanyi NsoforABUJA, Nov 7 2019 (IPS) Free movement of people and goods across Africa increases the risk of transmission of infectious diseases. The continent must realise that it is no longer a question of if disease outbreaks will occur, but instead, of when, and how fast. The U.S. Centres for Disease Control says that within 36 hours, a disease outbreak can spread from a remote village to major urban cities of the world. According to preventepidemics.org, a website which ranks countries’ levels of e...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Headlines Health Poverty & SDGs Source Type: news
by V íctor Hugo Peña-García, Rebecca C. Christofferson Chikungunya virus (CHIKV) emerged in Colombia in 2014 into a population presumed fully susceptible. This resulted in a quick and intense spread across Colombia, resulting in an epidemic that affected an estimated 450,000 people. The reported Colombian cases accounted for over 49% of all the cases reported to the PAHO. Eco-environmental factors are known to be associated with the spread of arboviruses such as CHIKV, and likely contribute to the differences in transmission profiles that were observed across several municipalities. To determine the a...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Publication date: Available online 5 November 2019Source: EpidemicsAuthor(s): Iain S. Koolhof, Katherine B. Gibney, Silvana Bettiol, Michael Charleston, Anke Wiethoelter, Anna-Lena Arnold, Patricia T. Campbell, Peter J. Neville, Phyo. Aung, Tsubasa Shiga, Scott Carver, Simon M. FirestoneAbstractRoss River virus (RRV) is Australia’s most epidemiologically important mosquito-borne disease. During RRV epidemics in the State of Victoria (such as 2010/11 and 2016/17) notifications can account for up to 30% of national RRV notifications. However, little is known about factors which can forecast RRV transmission in Victoria...
Source: Epidemics - Category: Epidemiology Source Type: research
It’s been a rough fall for Juul. After weeks of intensifying scrutiny from federal regulators, resulting in plans to pull many of its products off the market entirely, the company was hit on Oct. 29 with an explosive lawsuit filed by a former financial executive at the company, who alleged that Juul knowingly sold at least a million contaminated mint-flavored nicotine pods earlier this year. The plaintiff, former senior vice president of global finance Siddharth Breja, claims he was wrongfully terminated for raising concerns about the sale of these pods. The claims, which Juul vigorously denied in a statement provide...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
This study describes the efforts and outcomes associated with the establishment of a clinical sample repository during the 2016 Zika virus epidemic. To overcome the challenge of limited access to clinical samples to support diagnostic test development, multiple US Department of Health and Human Services (HHS) agencies formed a partnership to create the HHS Zika Specimen Repository. In 2016-2017, the Biomedical Advanced Research and Development Authority and the Centers for Disease Control and Prevention collected patient specimens (4420 convalescent sera aliquots from 100 donors and 7171 plasma aliquots from 239 donors), c...
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
Publication date: Available online 4 November 2019Source: Journal of Theoretical BiologyAuthor(s): Bo Xu, Jun Cai, Daihai He, Gerardo Chowell, Bing XuAbstractMultiple-wave outbreaks have been documented for influenza pandemics particularly in the temperate zone, and occasionally for seasonal influenza epidemics in the tropical zone. The mechanisms shaping multiple-wave influenza outbreaks are diverse but are yet to be summarized in a systematic fashion. For this purpose, we described 12 distinct mechanistic models, among which five models were proposed for the first time, that support two waves of infection in a single inf...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Abstract Currently, the spread of antimicrobial resistance (AMR) is a global trend and poses a severe threat to public health. The causative agent of cholera, an extremely virulent disease with pandemic expansion, becomes more and more resistant to a wider range of drugs with every coming year. The Vibrio cholerae genome is highly flexible and adaptive; the acquisition of the SXT mobile element with a cluster of antibiotic resistance genes on it has marked a new stage in the adaptive evolution of the pathogen. The territory of Siberia and Russian Far East is free of cholera; however, in the 1970s and 1990s a numbe...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
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