Treatment approaches for older and oldest patients with diffuse large B-cell lymphoma – Use of non-R-CHOP alternative therapies and impact of comorbidities on treatment choices and outcome: A Humedica database retrospective cohort analysis, 2007–2015

Publication date: Available online 12 August 2019Source: Journal of Geriatric OncologyAuthor(s): Vicki A. Morrison, Laurie Hamilton, Augustina Ogbonnaya, Aditya Raju, Kristin Hennenfent, Aaron GalaznikAbstractIntroductionWe characterized real-world treatment patterns in older (65–74 years) and oldest (75–85 years) patients with diffuse large B-cell lymphoma (DLBCL) receiving initial therapy (R-CHOP, non-R-CHOP regimens). Impact of comorbidities on treatment choice, and overall and progression-free survival (OS, PFS) were assessed by age.Patients and MethodsUsing the Humedica database, we identified 1436 newly diagnosed patients with DLBCL who received frontline therapy from 1/07–9/15. The 885 patients ≥65 years of age were further evaluated for baseline demographics, comorbidities, initial therapy, and PFS/OS.ResultsOf 885 patients, 406 (45.9%) were age 65–74, and 479 (54.1%) age 75–85, years. First line therapy was R-CHOP (61.8%) or non-R-CHOP (38.2%). Although Charlson Comorbidity Index (CCI) scores were similar at baseline, congestive heart failure and myocardial infarction were more common in those receiving non-R-CHOP regimens. Survival outcomes were superior for those receiving initial R-CHOP, versus non-R-CHOP, therapy (median PFS 53.9 versus 27.8 months; two-year PFS 71.2% versus 51.6%, p 
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research

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ConclusionsOur discussion details a comprehensive literature review of extramedullary pulmonary involvement in Waldenstrom ’s macroglobulinemia. Establishing a malignant etiology for pleural effusion in Waldenstrom’s macroglobulinemia can be challenging, as standard techniques may be insensitive. Allele-specific polymerase chain reaction for detecting MYD88 L265P mutations is more sensitive for confirming lymphoplas macytic lymphoma/Waldenstrom’s macroglobulinemia in pleural fluid. Extramedullary pulmonary involvement usually presents post-diagnosis of Waldenstrom’s macroglobulinemia and responds we...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 12 July 2020Source: Indian Heart JournalAuthor(s): Yash Paul Sharma, Kewal Kanabar, Krishna Santosh, Ganesh Kasinadhuni, Darshan Krishnappa
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Publication date: September 2020Source: American Heart Journal, Volume 227Author(s): Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, Pablo Martinez-Amezcua, Alejandro Cabello-López, Gabriela Alanis-Estrada, Abraham Luna-Herbert, Héctor González-Pacheco, Cynthia Paola Paredes-Paucar, Martinez Daniel Sierra-Lara, Jose Luis Briseño-De la Cruz, Hugo Rodriguez-Zanella, Marco Antonio Martinez-Rios, Alexandra Arias-Mendoza
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 13 June 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Thejus T. Jayakrishnan, Veli Bakalov, Yazan Samhouri, Rodney E. Wegner, Santhosh Sadashiv
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/ Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissue...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A HEART ATTACK occurs when the supply of blood to the heart is suddenly blocked. Although it is a medical emergency, you could have one without realising it. Pain in which arm could signal the deadly condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: Our study reports risk factors associated with mortality in ACS patients. Advanced and timely therapeutic measurements are likely to reduce the incidence of mortality in these patients. PMID: 32646364 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
Authors: Wang Y, Ding W Abstract The increased use of several effective novel targeted therapy agents has revolutionized therapy for patients with chronic lymphocytic leukemia (CLL). Disease progression in patients with CLL continues to occur, however. In particular, 3% to 25% of patients treated with a novel agent develop Richter transformation (RT); that is, histologic transformation of CLL to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RT that develops in the novel agent era is frequently associated with adverse molecular alterations, such as TP53 disruption and complex karyotype...
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
ang Ee-Chon Teo Yaodong Gu Traditional Chinese exercise (TCE) has gradually become one of the widespread complementary therapies for treatment and recovery of cancers. However, evidence based on the systematic evaluation of its efficacy is lacking, and there appears to be no conclusion regarding the setting of TCE interventions. The purpose of this systematic review is to summarize the current randomized controlled trials (RCTs) that outline the effects of TCE on cancer patients. Relevant studies were searched by GOOGLE SCHOLAR, SCIENCEDIRECT, and WEB OF SCIENCE using “traditional Chinese exercise&rdq...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
AbstractChildren with ventricular septal defects (VSDs) are subjected to hemodynamic overload which causes myocardial injury and subsequent heart failure. Early stages of myocardial damage cannot be detected by conventional echocardiography. Two-dimensional speckle tracking echocardiography (2D-STE) and cardiac troponin I (cTnI) have been recently introduced as more accurate tools for early assessment of cardiovascular diseases. The purpose of this study is to evaluate the role of cardiac troponin I (cTnI) and 2D-STE in the early detection of VSD-induced myocardial injury. Thirty children with VSD (symptomatic and asymptom...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
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