Oxidants Regulated Diaphragm Proteolysis during Mechanical Ventilation in Rats

Conclusions Prolonged controlled mechanical ventilation activates the proteasome and autophagy pathways in the diaphragm through oxidative stress. Pathway activation is accomplished, in part, through inhibition of microRNAs that negatively regulate autophagy-related genes.
Source: Anesthesiology - Category: Anesthesiology Source Type: research