Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

Estrogen-like female sex hormones at concentrations present in human placenta induce apoptosis. They do so by binding to phosphodiesterase 3A, which in turn recruits and stabilizes Schlafen 12 protein, whose elevated level stops the protein translation on ER, resulting in downregulation of anti-apoptotic proteins Bcl-2 and Mcl-1 and subsequent apoptosis.

Source: Molecular Cell - August 12, 2019 Category: Cytology Authors: Dianrong Li, Jie Chen, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huangwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbin Qi, Xiaodong Wang Tags: Article Source Type: research