DNA damage and adverse neurological outcomes among garlic farmers exposed to organophosphate pesticides
Publication date: Available online 12 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ratana Sapbamrer, Surat Hongsibsong, Nalin Sittitoon, Patchareeya AmputAbstractGarlic farmers used organophosphate pesticides to control insects, resulting in an increased risk for adverse health outcomes. Thus, we investigated exposure to organophosphate pesticides, DNA damage, nerve conduction, and neurological symptoms among 134 garlic farmers. They were interviewed, measured nerve conduction, and collected blood and urine for determining DNA damage and dialkylphosphate metabolites. Total dialkylphosphate levels of farmers who began cultivating garlic in October were significantly higher than those of non-farmers and the farmers who began cultivating in November and December. Farmers showed significantly longer comet tail lengths and tail moments than non-farmers. However, their mean compound motor and sensory nerve action potential amplitudes of the median, ulnar, and common peroneal nerves were within normal ranges. Measurement of DNA damage is useful as a biomarker of long-term and low-level exposure to organophosphate pesticides; however, electromyography might be not sufficiently sensitive to detect nerve conduction effects in farmers exposed to pesticides.
Conclusions: Results of the present study support the interpersonal theory of suicide, which suggests that self-reported thwarted belongingness can foster WD. Clinical implications: Clinicians should consider social dissatisfaction and withdrawal as risk factors for WD and design interventions that foster social skills or meaningful connections. PMID: 31615349 [PubMed - as supplied by publisher]
CONCLUSIONS: we found an association between SIBO and allergic disease, especially allergic rhinitis, cow's milk protein allergy and asthma. Thus, SIBO should be ruled out in pediatric patients with CAP and allergic disease. PMID: 31617366 [PubMed - as supplied by publisher]
CONCLUSIONS: this meta-analysis supported the association of AF with increased risk of GERD. PMID: 31617365 [PubMed - as supplied by publisher]
CONCLUSION: these data support the hypothesis that the hepatitis C virus may worsen quality of life in asymptomatic patients. PMID: 31617364 [PubMed - as supplied by publisher]
We report a case of a 67-year-old female presented with hematemesis eventually diagnosed with duodenal mucormycosis, while radiology characteristics suggested malignancy. PMID: 31617363 [PubMed - as supplied by publisher]
Authors: Taki S, Maekita T, Sakata M, Fukatsu K, Maeda Y, Iguchi M, Ito H, Kitano M Abstract Continuous duodenal levodopa/carbidopa intestinal gel delivery by a gastrostomy infusion system improves control of Parkinson's disease. The overall complication rates of percutaneous endoscopic gastrojejunostomy were reported to be 41% and 59% for immediate and delayed adverse events, respectively. A 72-year-old woman underwent percutaneous endoscopic gastrojejunostomy using the delivery system noted above. Abdominal pain and vomiting occurred 3 months later. Esophagogastroduodenoscopy showed a longitudinal ulcer extending...
Conclusions: Our study is the first to report that endoscopic therapy of PFCs using LAMS is safe and effective even in a community hospital setting with limited resources and support compared to large academic centers. PMID: 31615198 [PubMed - as supplied by publisher]
Authors: Krill TS, Chatila A, Marcondes F, Samuel R, Guturu P, Parupudi S Abstract PMID: 31617699 [PubMed - in process]
Authors: Adu-Tei S, Penny HA, El-Fekhi M, Ruse C, Sanders DS Abstract PMID: 31617698 [PubMed - in process]
Authors: Ramai D, Shahnazarian V, Etienne D, Ayide G, Reddy M Abstract PMID: 31617697 [PubMed - in process]