Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series.

Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series. Br J Ophthalmol. 2019 Aug 10;: Authors: Majithia S, Tham YC, Chee ML, Teo CL, Chee ML, Dai W, Kumari N, Lamoureux EL, Sabanayagam C, Wong TY, Cheng CY Abstract BACKGROUND/AIMS: In order to address the eye care needs of the increasing numbers of elderly Chinese globally, there is a need for comprehensive understanding on the longitudinal trends of age-related eye diseases among Chinese. We herein report the key findings from the baseline Singapore Chinese Eye Study (SCES-1), and describe the rationale and methodology of the 6-year follow-up study (SCES-2). METHODS: 3353 Chinese adults who participated in the baseline SCES-1 (2009-2011) were invited for the 6-year follow-up SCES-2 (2015-2017). Examination procedures for SCES-2 included standardised ocular, systemic examinations and questionnaires identical to SCES-1. SCES-2 further included new examinations such as optical coherence tomography angiography, and questionnaires to evaluate health impact and economic burden of eye diseases. RESULTS: In SCES-1, the age-adjusted prevalence of best-corrected low vision (VA
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research

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CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This is the second partnership that Singapore-headquartered Doctor Anywhere has announced in Vietnam in a period of about two months.
Source: mobihealthnews - Category: Information Technology Source Type: news
Authors: Campos-Borges HC, Sanz-González SM, Zanón-Moreno V, Millán Salvador JM, Pinazo-Duran MD PMID: 31629562 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
In this study, we assessed effects of LPZ on adipocyte differentiation and function by using 3T3-L1 preadipocytes and HFD-induced obesity mice as an in vitro and in vivo model, respectively.Main methodsOil red O staining and intracellular triacylglycerol content were used to determine lipid accumulation. Glucose uptake was performed to measure mature adipocyte function. Expression of adipocyte genes was determined by qRT-PCR and immunoblotting.Key findingsLPZ has dual effects on differentiation of 3T3-L1 cells. At low concentrations, LPZ enhanced adipocyte differentiation via induction of PPARγ and C/EBPα, two ...
Source: Life Sciences - Category: Biology Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Publication date: Available online 20 October 2019Source: Microvascular ResearchAuthor(s): Wayne Smith, Konstantin E. Kotliar, Leandi Lammertyn, Nthai E. Ramoshaba, Walthard Vilser, Hugo W. Huisman, Aletta E. SchutteAbstractPurposeGlobally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults.MethodsW...
Source: Microvascular Research - Category: Biochemistry Source Type: research
Cavero et  al.1 recently reported the frequency and severity of hypertension in a cohort of 55 patients with atypical hemolytic uremic syndrome (aHUS). A major complication of hemolytic uremic syndrome is hypertensive crisis related to juxtaglomerular ischemia and renin angiotensin system activation. However , hypertensive crisis has been also described as a cause of thrombotic microangiopathy because of endothelial shear stress. Despite the persistent incidence of hypertensive crisis in developed and developing countries,2 the pathophysiological mechanisms and treatment of hypertensive crisis–associa ted hemoly...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
We thank El Karoui and colleagues for their comments.1 We think that both studies, theirs and ours,2,3 show that severe hypertension is a characteristic feature of atypical hemolytic uremic syndrome (aHUS). Even their patients classified as aHUS not associated with hypertensive emergencies had a median blood pressure of 154/90 mm  Hg, which would include hypertension grades 1-2, according to the 2018 European Society of Cardiology/European Society of Hypertension guidelines.4 Unlike in their study, we found a favorable effect of eculizumab also in patients with severe and malignant hypertension.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
A 59-year-old woman presented with extreme thirst. She was a current smoker (35 pack-years) and had extensive peripheral vascular disease, including asymptomatic carotid artery stenosis. She had hypertension that was well regulated with a calcium channel blocker (nifedipine 30 mg once daily). Her thirst had become gradually worse over 6 months and was affecting her quality of life. During outpatient evaluation at a regional hospital, her thirst was accompanied by polydipsia and polyuria (both ∼6 l/d).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Herrero-Vanrell R Abstract Pathologies affecting the optic nerve and the retina are one of the major causes of blindness. These diseases include age-related macular degeneration (AMD), diabetic Retinopathy (DR) and glaucoma, among others. Also, there are genetic disorders that affect the retina causing visual impairment. The prevalence of neurodegenerative diseases of the posterior segment are increased as most of them are related with the elderly. Even with the access to different treatments, there are some challenges in managing patients suffering retinal diseases. One of them is the need for frequent interventi...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Tags: Adv Drug Deliv Rev Source Type: research
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