Laboratory evaluation of secondary causes of bone loss in Veterans with spinal cord injury and disorders

ConclusionsScreening for secondary causes of osteoporosis, particularly for hypogonadism and hypovitaminosis D, should be considered in patients with a SCI/D.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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This study is a prospective clinical study. Purpose: This study aims to evaluate the characteristics of trunk musculature and intervertebral discs by using magnetic resonance imaging in patients with spinal cord injuries (SCIs) with thoracic and lumbar fractures. Overview of Literature: Muscle atrophy is an immediate consequence of SCI and is associated with secondary complications. At present, there are limited clinical data on muscle and disc responses to fractures of the thoracic and lumbar spine. Methods: A total of 51 patients with a mean age of 31.75±10.42 years who suffered traumatic SCI were incl...
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Publication date: Available online 28 March 2020Source: Journal of OrthopaedicsAuthor(s): Daniel T. Miles, Ryan T. Voskuil, Wood Dale, Joel L. Mayerson, Thomas J. Scharschmidt
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Publication date: Available online 27 March 2020Source: Joint Bone SpineAuthor(s): Krishna Prabha Gautam, Remya Rajan, Kripa Elizabeth Cherian, Nitin Kapoor, Julie Hephzibah, Thomas Vizhalil Paul
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 27 March 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): A. Roquilly, B. Vigué, M. Boutonnet, P. Bouzat, K. Buffenoir, E. Cesareo, A. Chauvin, C. Court, F. Cook, A.C. de Crouy, P. Denys, J. Duranteau, S. Fuentes, T. Gauss, T. Geeraerts, C. Laplace, V. Martinez, J.F. Payen, B. Perrouin-Verbe, A. Rodrigues
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Abstract Following nerve tissue damage, various events, such as inflammatory responses, microglial activation, endoplasmic reticulum stress, and apoptosis, can occur, which all lead to cell death, prevent axonal growth, and cause axonal circumvolution. So far, several researchers have tended to adopt strategies to reduce the harmful conditions associated with neurological disorders, and stem‑cell‑based therapy is one of those promising strategies. Epidermal neural crest stem cells (EPI‑NCSCs) are a type of stem cell that has widely been employed for the treatment of various neurological disorders. It has bee...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
Conclusion: Our study indicated that distinctive patterns of FC in each subregion of insula suggest that the insular subareas participate in the NP processing through different FC following ISCI. Further, insula subregions could serve as a therapeutic target for NP following ISCI. PMID: 32211038 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
STUDY DESIGN: Descriptive study. OBJECTIVES: The aim of this manuscript is to describe the development process of the data set for the National Spinal Cord Injury Registry of Iran (NSCIR-IR). SETTING: SCI community in Iran. METHODS: The NSC...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
AbstractPurpose of ReviewThe molecular mechanisms of the bone disease associated with chronic kidney disease (CKD), called renal osteodystrophy (ROD), are poorly understood. New transcriptomics technologies may provide clinically relevant insights into the pathogenesis of ROD. This review summarizes current progress and limitations in the study and treatment of ROD, and in transcriptomics analyses of skeletal tissues.Recent FindingsROD is characterized by poor bone quality and strength leading to increased risk of fracture. Recent studies indicate permanent alterations in bone cell populations during ROD. Single-cell trans...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewHyperparathyroidism may be due to an autonomous hypersecretion of parathyroid hormone (PTH) or occurs in response to a number of physiological stimuli. A number of recent findings have provided new insights into the importance of the calcium-parathyroid-vitamin D axis to bone in normal physiology and pathological conditions.Recent FindingsPTH is known to affect bone microarchitecture with different effects on cortical and trabecular bone compartments. In trabecular bone, PTH may exert anabolic effects, whereas PTH promotes bone resorption in cortical bone. Vertebral fractures are prevalent in prima...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Asiatic acid is a triterpenoid compound extracted from a medicinal plant Centella asiatica. It has been used as a highly efficient compound for the treatment of cancer and hyperlipidemia, as well as possessing potential antiinflammatory properties. However, its effects on bone metabolism and osteoporosis haven’t been reported. The purpose of our research were to reveal the biomolecular effects of asiatic acid on osteoclasts, and its underlying molecular mechanisms regulating its effects on receptor activator of NF-κB ligand (RANKL)-induced signaling pathways. We found that asiatic acid inhibited multinucleated ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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