CAD and Cardiovascular Events After Liver Transplantation CAD and Cardiovascular Events After Liver Transplantation

Is the risk of cardiovascular events during the immediate period after liver transplant associated with the presence or severity of pre-existing coronary artery disease?Liver International
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

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Clinical Pathologic Mismatch in a TNF-α Inhibitor-Associated Drug Reaction J Drugs Dermatol. 2019 Aug 01;18(8):828-830 Authors: O’Brien KF, Maiman RE, DeWitt CA Abstract A 56-year-old Caucasian male with a history of chronic plaque psoriasis, primary sclerosing cholangitis status-post liver transplant on tacrolimus, and ulcerative colitis on infliximab developed a progressive erythematous eruption with associated fatigue, anorexia, myalgias, and arthralgias. On two separate occasions, his skin biopsy demonstrated a lichenoid interface dermatitis (LID). Despite multiple courses of oral predn...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
This study found that liver transplant patients are at high risk of developing cardiovascular events post transplantation, even with no pre-existing risk factors. Can predictors be determined?Liver International
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Transplantation Journal Article Source Type: news
Abstract Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 106 stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibite...
Source: Biotechnic and Histochemistry - Category: Research Authors: Tags: Biotech Histochem Source Type: research
In this study, we investigate the therapeutic effects of ASCs in a rat model of CCl4-induced liver fibrosis. Rats were treated with ASCs for 4  weeks in vivo, then biochemical and histopathological analyses were performed. Furthermore, we established cell co-culture systems of hepatic stellate cells (HSCs) and ASCs and of M1 macrophages and ASCs in vitro. Mesenchymal stem cells (MSCs) were used as a positive control. The results showed th at ASC transplantation alleviated liver fibrosis effectively as evidenced by reduced collagen accumulation, decreased fatty degeneration, increased hepatocyte regeneration, decreased...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 17 August 2019Source: Cirugía Española (English Edition)Author(s): Luis M. Marín-Gómez, Gonzalo Suárez-Artacho, Javier Padillo-Ruiz, Miguel A. Gómez-Bravo
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 16 August 2019Source: IDCasesAuthor(s): Nicholas Cheronis, Dustin Carr, Nitin BhanotAbstractNocardiosis is a potentially life-threatening infection that affects both immunocompetent and immunosuppressed hosts. We discuss a case of an elderly gentleman with history of orthotopic liver transplantation who presented with cellulitis of his left forearm. When he did not respond to the typical antibiotic coverage for bacterial cellulitis, skin biopsy was performed. N. arthritidis was identified as the pathogen, a relatively newly identified human pathogen first described to cause human disease in 2004.
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 August 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Manon Allaire, Hélène GilgenkrantzSummaryThe aging of the population, the increased prevalence of chronic liver diseases in elderly and the need to broaden the list of potential liver donors enjoin us to better understand what is an aged liver. In this review, we provide a brief introduction to cellular senescence, revisit the main morphological and functional modifications of the liver induced by aging, particularly concerning metabolism, immune response and regeneration, and try to elud...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Hepatocellular carcinoma (HCC) is one of the quickest growing causes of cancer death in the northern hemisphere. Transplant and resection, the only treatments considered curative, are feasible in only a small minority of patients. Consequently, the landscape of HCC treatment has greatly expanded over the past 10 years. Patients are undergoing treatment with a wide variety of nonoperative interventions, including transarterial chemoembolization and radioembolization using Yttrium-90, and an expanding array of systemic treatments, including sorafenib, regorafenib, and nivolumab.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
BC Transplant says a misunderstanding about the guidelines concerning alcohol abstinence and liver transplants triggered a human rights complaint filed earlier this week by a B.C. man who has end-stage liver disease.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
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