Superbug C. difficile is evolving to 'spread in hospitals and thrive on the Western diet' 

Scientists from the London School of Hygiene &Tropical Medicine discovered the bacteria Clostridium difficile, which causes diarrhoea, is gradually 'splitting' into two species.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise it is named pseudo-placebo. Therapeutic methods with unproven effects should be tested in high quality research shielded from the funding bias. Some issues discussed in this review are not entirely clear, and the arguments provided here can initiate a constructive discussion. PMID: 31424374 [PubMed - as supplied by publisher]
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
Publication date: Available online 19 August 2019Source: Trends in Food Science &TechnologyAuthor(s): Qingying Fang, Jielun Hu, Qixing Nie, Shaoping NieAbstractBackgroundAs an important role of host homeostasis, the glycometabolism was closely related to the process and metabolic pathways of carbohydrates such as glycolysis, hexosamine biosynthetic pathway, and pentose phosphate in the host. Disorders of glycometabolism result in a series of metabolic diseases, such as diabetes, obesity, hypoglycemia, and etc.Scope and approachPolysaccharides, which were widely existing in daily diet and cannot be directly digested by ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 19 August 2019Source: Trends in Food Science &TechnologyAuthor(s): Carolina Fernanda Sengling Cebin Coppa, Amin Mousavi Khaneghah, Paula Alvito, Ricardo Assunção, Carla Martins, Ismail Eş, Bruna Leonel Gonçalves, Diane Valganon de Neeff, Anderson S. Sant'Ana, Carlos Humberto Corassin, Carlos Augusto Fernandes OliveiraAbstractBackgroundBreast milk is considered an essential food segment for children up to 6 months; however, it can be contaminated with some mycotoxins, such as aflatoxin M1 (AFM1) and ochratoxin A (OTA) as a consequence of ingestion of dietary mycot...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
This study aimed to assess, by molecular studies, the virulent nature of some Bacillus strains in live edible snails (Achatina achatina) sold in Nigerian markets and to ascertain the survival of bacilli during culinary preparation. Results showed that isolates with high virulence potentials were B. thuringiensis and two strains of B. cereus (GenBank accession numbers: MK530172, MK530171 and MK530202). The nheb gene was detected in all three isolates, while B. thuringiensis strain was found to possess hbla, nhea, nheb and cytk genes for enterotoxins often implicated in diarrhoea cases. Most isolates were resistant to chlora...
Source: Food Control - Category: Food Science Source Type: research
In this study, a method for the quantification of wine stilbenes has been developed and validated. The method was simple, fast and sensitive with LOD between 4 and 28 μg/L. Matrix effects were assessed, and the methodology was validated in terms of precision, accuracy, linearity and repetitiveness. The method was able to quantify, in less than 5 min, fifteen targeted stilbenes in wines including seven monomers, three dimers, one trimer, and four tetramers. The methodology was applied to white and red wines. E-piceid was the main stilbene in white wine (mean 155 μg/L). In red wine, Z- and E-piceid (mean 3.73 and...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 6 August 2019Source: Food ControlAuthor(s): Sarina Pradhan Thapa, Smriti Shrestha, Anil Kumar AnalAbstractAntibiotics are the compounds widely used to treat bacterial infections in human and variety of agricultural sectors including livestock farming, plants and crops, and aquaculture. However, rampant and uncontrolled use of antibiotics results in the emergence of resistant bacterial strains. Such resistant strains on the food chain possibly increase the risk of antibiotic resistant foodborne pathogens. Antibiotic resistant bacteria can reach human either directly via the contact with th...
Source: Food Control - Category: Food Science Source Type: research
This study investigated the experiences of the Kaingang and Guarani Indigenous peoples from the South of Brazil regarding the effects of cultural changes on their food systems and oral status. Focus groups were conducted in each tribe and the methodological framework grounded theory was adopted. The development of categories occurred with reference to Pierre Bourdieu's work. Four themes emerged from the analysis: 1. Contemporary Indigenous identities; 2. Perceptions of food systems; 3. Shared knowledge in the orientation of differentiated assistance in oral health; and 4. Ethnic cultural capital in conflict. The food trans...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
Clostridium difficile infection (CDI) is the leading cause of nosocomial antibiotic-associated diarrhoea and colitis, and is associated with high mortality and soaring healthcare costs [1]. The recommended treatment of adults with severe CDI is oral vancomycin or oral fidaxomicin [2]. Oral vancomycin is also recommended for children with severe or fulminant CDI [2]. However, the rising incidence of CDI since 2000, together with the frequency of relapses and emergence of hypervirulent and antibiotic-resistant strains, has increased the urgency for new treatments [3,4].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
SAND play pits harbour the emerging superbug C. diff that causes stomach upsets and diarrhoea and in rare cases damages the gut, a new study found.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions Oral vancomycin induces drastic and consistent changes in the human intestinal microbiota. Upon vancomycin cessation, the microbiota recovery rate varied considerably among subjects, which could influence, as validated in mice, the level of susceptibility to pathogen intestinal colonization. Our results demonstrate the negative long-term effects of vancomycin, which should be considered as a fundamental aspect of the cost–benefit equation for antibiotic prescription.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Authors: Tags: Original research Source Type: research
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