Prevalence of Paroxysmal Nocturnal Hemoglobulinura Clones in Myeloproliferative Patients- a Cross Sectional Study

PNH and MPN are diseases associated with increased thrombosis. PNH clones are commonly found in other haematological diseases i.e. MDS and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research

Related Links:

Publication date: November–December 2019Source: Journal of Orthopaedics, Volume 16, Issue 6Author(s): Bhaveen H. Kapadia, Barrett B. Torre, Nicholas Ullman, Andrew Yang, Matthew A. Harb, Preston W. Grieco, Jared M. Newman, Steven F. Harwin, Aditya V. MaheshwariAbstractTotal hip and knee arthroplasties may be associated with a significant amount of perioperative blood loss. The severity of blood loss may be great enough to require the use of blood transfusions to treat perioperative anemia. Various methods of blood preservation have been studied. The use of antifibrinolytics and antifibrinolytic-like agents to reduce ...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Publication date: November–December 2019Source: Journal of Minimally Invasive Gynecology, Volume 26, Issue 7, SupplementAuthor(s): T Guo, C Liu, Z ZhangStudy ObjectiveThe aim of this study was to examine the applicability of the Caprini risk assessment model and gynecologic Caprini risk assessment model for postoperative venous thromboembolism risk assessment in gynecologic surgical patients and make a comparison between the two risk assessment models.DesignA database of a randomized controlled trial was employed. Scores of Caprini and gynecologic Caprini risk assessment model were calculated for each patient. Patien...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionSame-day discharge after vaginal hysterectomy with pelvic floor reconstruction appears to be safe and feasible. Patients who were discharged the same-day did not require a higher volume of emergency department or office evaluations.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Authors: Grover SP, Mackman N Abstract The ferric chloride models of arterial thrombosis are useful tools with which to investigate the cellular and molecular mechanisms that contribute to arterial thrombosis. Recent insights have, however, revealed the complex and multifaceted mechanism by which ferric chloride induces thrombus formation. Here, we discuss the strengths and weaknesses of the ferric chloride models of arterial thrombosis. Particular focus is given to the phenotypes of different knockout mice in the ferric chloride models and how these compare to other models with independent modes of initiation. Fur...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
We present a challenging case of recurrent acute coronary syndrome, in the context of very high thrombotic risk due to concomitant inflammatory disease. Although no general guidelines exist for the switch between antiplatelet agents, particularly in the acute setting, in specific cases, the availability of different orally- and i.v.-acting agents and platelet function tests may allow to discriminate among multiple possible mechanisms of drug failure or side effects in the individual patient. PMID: 31607192 [PubMed - as supplied by publisher]
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
We report a 65-year-old female with non-Hodgkin’s lymphoma who developed native valve infective endocarditis due to Micrococcus luteus. There is no defined therapeutic regimen for infective endocarditis due to Micrococcus luteus; however, our patient was successfully treated for six weeks with vancomycin and rifampin. To our knowledge, there is only one other case report of native valve endocarditis due to Micrococcus luteus.
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 14 October 2019Source: IDCasesAuthor(s): Jaineel Ramnarain, Jang Yoon, Naomi RunnegarAbstractStaphylococcus pasteuri is a coagulase negative bacterium which although formally described in 1993, has only recently become possible to reliably speciate in diagnostic microbiology laboratories. S. pasteuri remains an extremely infrequent cause of human infection to date, namely bacteremia in an individual suffering acute myeloid leukemia, catheter-associated urinary tract infection in a patient receiving chemotherapy and endocarditis within a case series without specific clinical information. A...
Source: IDCases - Category: Infectious Diseases Source Type: research
This study is registered with the ISRCTN registry, number ISRCTN49407852, and clinicaltrialsregister.eu, number 2009–010956–93, and has completed recruitment.FindingsBetween Nov 15, 2010, and July 28, 2016, 583 patients were enrolled to the intensification randomisation, representing 48% of the 1217 patients who achieved partial or minimal response after initial induction therapy. 289 patients were assigned to CVD treatment and 294 patients to no treatment. After a median follow-up of 29·7 months (IQR 17·0–43·5), median progression-free survival was 30 months (95% CI 25–36) with...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: Available online 14 October 2019Source: The Lancet HaematologyAuthor(s): Francesca Patriarca
Source: The Lancet Haematology - Category: Hematology Source Type: research
AbstractPercutaneous left atrial appendage closure (LAAC) may decrease risks of stroke and bleeding in elderly patients with non-valvular atrial fibrillation (NVAF), but it is still lacking of evidence. The present study aimed at evaluating the efficacy and safety of LAAC in patients with NVAF over 75  years. 351 patients with NVAF who underwent LAAC were retrospectively analyzed on the LAAC procedure characteristics and the clinical follow-up according to age (age ≥ 75 years or 
Source: Heart and Vessels - Category: Cardiology Source Type: research
More News: Anemia | Aplastic Anemia | Hematology | Leukemia | Lymphoma | Myeloma | Myeloproliferative Disorders | Study | Thrombosis